Evans David A, Wu Jimmy
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
J Am Chem Soc. 2005 Jun 8;127(22):8006-7. doi: 10.1021/ja0522130.
An enantio- and diastereoselective carbonyl-ene reaction catalyzed by chiral scandium pyridyl bis(oxazoline) (pybox) complexes has been developed. Uniformly high enantiomeric excesses and good yields were observed. Use of trisubstituted olefins generated the syn product in high enantio- and diastereoselectivity.
已开发出手性钪吡啶基双（恶唑啉）（pybox）配合物催化的对映体和非对映体选择性羰基-烯反应。观察到对映体过量率始终很高且产率良好。使用三取代烯烃以高对映体和非对映体选择性生成顺式产物。
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