手性 Sc 催化的硫醇与烯酮在水中的不对称迈克尔反应。
Chiral Sc-catalyzed asymmetric Michael reactions of thiols with enones in water.
机构信息
Department of Chemistry, School of Science and Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
出版信息
Org Biomol Chem. 2011 May 21;9(10):3619-21. doi: 10.1039/c1ob05424d. Epub 2011 Apr 7.
PMID:21472183
Abstract
Asymmetric Michael reactions of thiols with enones were catalyzed by a Sc(OTf)(3)-chiral bipyridine complex at room temperature in water without using any organic solvents, to afford the desired sulfides in high yields with high enantioselectivities.
摘要
手性双吡啶钪(III)配合物催化硫醇与烯酮的不对称迈克尔加成反应在室温、无需使用有机溶剂的条件下于水中进行，以高产率和高对映选择性得到了目标硫化物。
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