Smith Stephen M, Donio Michael J, Singh Mahender, Fallon James P, Jitendranath Lavanya, Chkrebtii Natalia, Slim Jihad, Finkel Diana, Perez George
Saint Michael's Medical Center, Newark, New Jersey 07102, USA.
Retrovirology. 2005 May 31;2:38. doi: 10.1186/1742-4690-2-38.
GBV-C virus infection has been linked to improved clinical outcome in HIV-1 co-infected individuals. The epidemiology of GBV-C has, thus far, been limited to the gay male, HIV+ population. Here we describe the prevalence of antibodies against GBV-C envelope glycoprotein E2 and GBV-C viremia in an HIV+ inner city population. This study group is predominantly African-American; 41% of the participants are women. The major risk factor for HIV infection is intravenous drug use. Overall, 56% of the study population had evidence of current or past infection with GBV-C. GBV-C exposure was not associated with hepatitis C virus infection. The group of participants, who had GBV-C viremia and anti-E2 antibodies, had high percentage of patients with an undetectable HIV-1 viral load. These data provide increased insight into the prevalence of GBV-C co-infection in the HIV epidemic in this understudied population.
GBV-C病毒感染与HIV-1合并感染个体临床结局的改善有关。迄今为止，GBV-C的流行病学仅限于男同性恋HIV阳性人群。在此，我们描述了市中心HIV阳性人群中抗GBV-C包膜糖蛋白E2抗体的流行情况以及GBV-C病毒血症情况。该研究组主要为非裔美国人；41%的参与者为女性。HIV感染的主要危险因素是静脉注射吸毒。总体而言，56%的研究人群有当前或既往GBV-C感染的证据。GBV-C暴露与丙型肝炎病毒感染无关。有GBV-C病毒血症和抗E2抗体的参与者组中，HIV-1病毒载量检测不到的患者比例很高。这些数据为深入了解这一研究不足人群中HIV疫情中GBV-C合并感染的流行情况提供了更多信息。
