de Hoyos Alberto, Fernando Hiran C
Cardiothoracic Surgery, Northwestern Memorial Hospital, 215 East Huron 10-105, Chicago, IL 60611, USA.
Surg Clin North Am. 2005 Jun;85(3):465-81, viii. doi: 10.1016/j.suc.2005.01.017.
Gastroesophageal reflux disease (GERD) is a chronic condition affect-ing over 7% of the US population. The primary objective of therapy is symptom relief, with secondary goals to heal esophagitis, prevent reflux-related complications, and maintain remission. There are several new endoscopic therapies (ETs) for treatment of GERD, generating considerable interest. An outpatient procedure, performed without an incision and general anesthesia, is attractive to patients and these therapies are being rapidly introduced, despite lack of long-term follow-up and randomized trials. In this article, the authors review endoscopic procedures, including technical aspects, mechanisms of action, safety, efficacy, and tolerability. Patient selection and relevant human studies are reviewed to clarify advantages and disadvantages of ET compared with conventional procedures.
胃食管反流病（GERD）是一种慢性病，影响着超过7%的美国人口。治疗的主要目标是缓解症状，次要目标是治愈食管炎、预防反流相关并发症并维持病情缓解。目前有几种用于治疗GERD的新型内镜治疗（ET）方法，引起了广泛关注。作为一种无需切口和全身麻醉的门诊手术，ET对患者具有吸引力，尽管缺乏长期随访和随机试验，但这些治疗方法仍在迅速推广。在本文中，作者回顾了内镜手术，包括技术方面、作用机制、安全性、有效性和耐受性。还回顾了患者选择和相关人体研究，以阐明ET与传统手术相比的优缺点。
