Woltman Todd A, Pellegrini Carlos A, Oelschlager Brant K
Department of Surgery, University of Washington, 1959 NE Pacific Street, Box 356410, Seattle, WA 98195-6410, USA.
Surg Clin North Am. 2005 Jun;85(3):483-93. doi: 10.1016/j.suc.2005.01.002.
Surgical therapy (Heller myotomy) is the most effective treatment to relieve dysphagia associated with achalasia. The advent of minimally invasive techniques, specifically the laparoscopic approach, significantly reduced the morbidity of surgical therapy, making it the procedure of choice for most patients who have achalasia. Pneumatic dilatation is a viable alternative, though is associated with inferior results and a higher risk of esophageal perforation than surgical therapy. Pharmacotherapy and Botox provide inferior results and should be reserved for temporizing therapy, or for patients who are deemed too frail for surgical intervention. For best results, a laparoscopic myotomy should be carried at least 3 cm onto the stomach, and a partial fundoplication should be performed to reduce the incidence of postoperative GE reflux.
手术治疗(赫勒肌切开术)是缓解贲门失弛缓症相关吞咽困难的最有效治疗方法。微创技术的出现,特别是腹腔镜手术方法,显著降低了手术治疗的发病率,使其成为大多数贲门失弛缓症患者的首选治疗方法。气囊扩张是一种可行的替代方法,但其效果不如手术治疗,且食管穿孔风险高于手术治疗。药物治疗和肉毒杆菌毒素治疗效果较差,应仅用于临时治疗,或用于被认为身体过于虚弱而无法接受手术干预的患者。为获得最佳效果,腹腔镜肌切开术应至少延伸至胃3厘米,并应进行部分胃底折叠术以降低术后胃食管反流的发生率。