Gutiérrez Rafael
Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados, Apartado Postal 14-740, México City, DF 07000, México.
Trends Neurosci. 2005 Jun;28(6):297-303. doi: 10.1016/j.tins.2005.04.005.
Markers of the glutamatergic and GABAergic phenotypes coexist in developing hippocampal granule cells, and activation of these neurons produces simultaneous glutamate-receptor-mediated and GABA-receptor-mediated responses in their postsynaptic cells. In the adult, markers of the GABAergic phenotype and the consequent GABAergic transmission disappear but can be transiently expressed in an activity-dependent manner. Coexistence of glutamate and GABA in neurons from other regions of the brain is being discovered, and the possibility of these neurotransmitters being co-released gives the CNS a powerful computational tool. Although waiting to be confirmed by paired recordings, the hypothesis that glutamate and GABA are co-released from single cells is a valuable heuristic proposal in understanding the plasticity inherent to neuronal communication.
谷氨酸能和γ-氨基丁酸能表型的标志物在发育中的海马颗粒细胞中共存，这些神经元的激活会在其突触后细胞中产生同时由谷氨酸受体介导和γ-氨基丁酸受体介导的反应。在成体中，γ-氨基丁酸能表型的标志物及随之而来的γ-氨基丁酸能传递消失，但可以以活动依赖的方式短暂表达。大脑其他区域的神经元中谷氨酸和γ-氨基丁酸共存的现象正在被发现，这些神经递质共同释放的可能性为中枢神经系统提供了一个强大的计算工具。尽管有待配对记录来证实，但谷氨酸和γ-氨基丁酸从单个细胞中共同释放的假说在理解神经元通讯固有的可塑性方面是一个有价值的启发式提议。
