Hestrin Shaul, Galarreta Mario
Department of Comparative Medicine, Stanford University School of Medicine, 300 Pasteur Drive, R314, Stanford, CA 94305-5342, USA.
Trends Neurosci. 2005 Jun;28(6):304-9. doi: 10.1016/j.tins.2005.04.001.
Recent work using paired recording has provided a direct demonstration of functional electrical synapses between neocortical neurons of both juvenile and adult animals. Electrical synapses have been found among GABAergic interneurons but not pyramidal cells. Interestingly, necortical electrical synapses almost exclusively connect GABAergic neurons belonging to the same class. So far, at least five different neocortical networks defined by extensive and selective electrical coupling have been studied in the neocortex. These results could provide important clues to the understanding of functional cortical circuitry.
近期使用配对记录法开展的研究直接证实了幼年和成年动物新皮层神经元之间存在功能性电突触。电突触已在GABA能中间神经元之间被发现，但在锥体细胞之间未被发现。有趣的是，新皮层电突触几乎仅连接属于同一类别的GABA能神经元。到目前为止，新皮层中至少有五个由广泛且选择性电耦合定义的不同新皮层网络已被研究。这些结果可能为理解功能性皮质回路提供重要线索。
