Hossain M, Chetana M, Devi P Uma
Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Post Box No. 32, Bhopal 462001, India.
Int J Dev Neurosci. 2005 Jun;23(4):307-13. doi: 10.1016/j.ijdevneu.2005.01.006.
We studied the changes in the brain weight and hippocampal histology in adult offspring exposed to 0.25-1.5 Gy of 60Co gamma radiations during day 14 or 17 of gestation. Irradiation with 0.5-1.5 Gy produced a significant decrease in brain weight of the offspring at 6 and 12 months of age. Exposure to 1 Gy at day 14 or 17 of gestation resulted in significant decrease in the number of neurons in the CA3 and CA4 regions of hippocampus of 200 microm length, while 1.5 Gy significantly affected CA1 region also. The fetal period (13-18 days of gestation) of mouse development is an active phase of brain development involving proliferation, migration and differentiation of cerebral cortex and associated structures. The present results show that exposure at this period of mouse development to moderate doses of gamma radiation can induce permanent deficits in the brain histology, which can adversely affect the learning and memory in adults.
我们研究了在妊娠第14天或第17天暴露于0.25 - 1.5 Gy的60Coγ射线的成年子代的脑重量和海马组织学变化。0.5 - 1.5 Gy的辐射使子代在6个月和12个月大时脑重量显著降低。在妊娠第14天或第17天暴露于1 Gy导致海马体CA3和CA4区域200微米长度内的神经元数量显著减少，而1.5 Gy也显著影响了CA1区域。小鼠发育的胎儿期（妊娠13 - 18天）是大脑发育的活跃阶段，涉及大脑皮层及相关结构的增殖、迁移和分化。目前的结果表明，在小鼠发育的这个时期暴露于中等剂量的γ射线可导致脑组织学的永久性缺陷，这可能对成年后的学习和记忆产生不利影响。
