Baskar R, Devi P U
Department of Radiobiology, Kasturba Medical College, Manipal, India.
Indian J Exp Biol. 1996 Sep;34(9):887-90.
Abdominal region of pregnant Swiss mice were exposed to 0.25, 0.35 or 0.50 Gy of gamma radiation on days 11.5, 12.5, 14.5 or 17.5 post coitus (pc). Changes in locomotory activity and learning performance, and hippocampal biogenic amines (noradrenaline, NA; dopamine, DA; 5-hydroxytryptomine, 5-HT; and 5-HTs metabolite 5-hydroxyindolacetic acid, 5-HIAA) were studied at 12 (adult) and 18 months (old) of age. Significant change in locomotory activity and learning performance was observed after exposure to 0.50 Gy at late organogenesis day (11.5 pc), when tested at 12 months of age, but not observed much change at 18 months. Biogenic amines did not show any significant change after any exposure dose at any of the gestation days. It was inferred from the results that gamma irradiation (0.50 Gy) at the late organogenesis (day 11.5 pc) can impair the brain functions in adults when normal faculties are functional.
在交配后（pc）第11.5、12.5、14.5或17.5天，对怀孕的瑞士小鼠腹部区域进行0.25、0.35或0.50 Gy的γ射线照射。在12个月（成年）和18个月（老年）时，研究了运动活动和学习能力的变化以及海马生物胺（去甲肾上腺素，NA；多巴胺，DA；5-羟色胺，5-HT；以及5-HT的代谢产物5-羟吲哚乙酸，5-HIAA）。在器官形成后期（11.5 pc）暴露于0.50 Gy后，12个月龄时测试发现运动活动和学习能力有显著变化，但18个月龄时未观察到明显变化。在任何妊娠天数的任何暴露剂量后，生物胺均未显示出任何显著变化。从结果推断，在器官形成后期（11.5 pc）进行γ射线照射（0.50 Gy），在正常功能发挥作用时，可能会损害成年小鼠的脑功能。
