Handen B L, Breaux A M, Janosky J, McAuliffe S, Feldman H, Gosling A
University of Pittsburgh School of Medicine, Department of Pediatrics, PA.
J Am Acad Child Adolesc Psychiatry. 1992 May;31(3):455-61. doi: 10.1097/00004583-199205000-00011.
Stimulant medication efficacy was evaluated in 14 children with attention-deficit hyperactivity disorder and IQs of 48 to 74 in a double-blind crossover study of two methylphenidate doses and placebo. Dependent measures included behavioral ratings, work output, measures of learning, attention and impulsivity, and direct observation of peer social interactions. Nine children (64%) were methylphenidate-responders, based upon the Conners Hyperactivity Index. Significant gains in on-task behavior and attentional skills were noted with methylphenidate in comparison to placebo. No improvement on measures of learning or social interactions were observed. Results extend and replicate previous research conducted by the authors.
在一项针对14名注意力缺陷多动障碍且智商在48至74之间的儿童的双盲交叉研究中，对两种哌甲酯剂量和安慰剂进行了兴奋剂药物疗效评估。相关测量指标包括行为评分、工作产出、学习、注意力和冲动性测量，以及对同伴社交互动的直接观察。根据康纳斯多动指数，9名儿童（64%）对哌甲酯有反应。与安慰剂相比，哌甲酯使专注任务行为和注意力技能有显著提升。在学习或社交互动测量方面未观察到改善。研究结果扩展并重复了作者之前进行的研究。
