Niemi Laura T, Suvisaari Jaana M, Haukka Jari K, Lönnqvist Jouko K
Department of Mental Health and Alcohol Research, KTL, National Public Health Institute, Mannerheimintie, Helsinki, Finland.
Schizophr Res. 2005 Jul 1;76(1):105-12. doi: 10.1016/j.schres.2004.11.004. Epub 2004 Dec 15.
The Helsinki High-Risk (HR) Study is a follow-up study of offspring (born between 1960 and 1964) of all females treated for schizophrenia spectrum disorders in mental hospitals in Helsinki before 1975, and controls.
To compare childhood growth among HR and control children, and to determine if any patterns in childhood growth predict later development of psychotic disorders within the HR group.
We accessed growth information from childhood health cards, which we obtained for 114 HR and 53 control offspring. The growth of HR children was compared with that of control children. Within the HR group, we investigated whether any association existed between childhood growth patterns and morbidity from psychotic disorders using logistic regression models.
The HR girls were shorter than controls at birth (p=0.030), but this disparity vanished by age 7. In contrast, HR boys were only slightly shorter at birth than controls, but the height difference increased with age, being statistically significant at 10 years (p=0.020). Among HR children, the combination of being in the lowest tertile for ponderal index at birth but in the highest tertile for BMI at 7 years predicted later development of schizophrenia (OR 22.8, 95% CI 2.0, >100, p=0.040).
Catch-up growth increases the risk of schizophrenia among offspring of mothers with psychotic disorder. Whether this is an independent risk factor or merely a reflection of some other risk factors needs further research.
赫尔辛基高危（HR）研究是一项对1975年前在赫尔辛基精神病院接受精神分裂症谱系障碍治疗的所有女性的后代（出生于1960年至1964年之间）及其对照进行的随访研究。
比较HR儿童与对照儿童的童年生长情况，并确定童年生长的任何模式是否能预测HR组中精神障碍的后期发展。
我们从儿童健康卡中获取生长信息，这些卡片是我们为114名HR后代和53名对照后代获取的。将HR儿童的生长情况与对照儿童进行比较。在HR组中，我们使用逻辑回归模型研究童年生长模式与精神障碍发病率之间是否存在关联。
HR组女孩出生时比对照组矮（p = 0.030），但这种差异在7岁时消失。相比之下，HR组男孩出生时仅比对照组略矮，但身高差异随年龄增加，在10岁时具有统计学意义（p = 0.020）。在HR儿童中，出生时体重指数处于最低三分位数但7岁时BMI处于最高三分位数的组合可预测后期精神分裂症的发生（OR 22.8，95% CI 2.0，>100，p = 0.040）。
追赶生长会增加患有精神障碍母亲的后代患精神分裂症的风险。这是一个独立的风险因素还是仅仅是其他一些风险因素的反映，需要进一步研究。
