Niemi Lauri T, Suvisaari Jaana M, Haukka Jari K, Lönnqvist Jouko K
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland.
Br J Psychiatry. 2005 Feb;186:108-14. doi: 10.1192/bjp.186.2.108.
The Helsinki High-Risk Study monitors women treated for schizophrenia-spectrum disorders in Helsinki mental hospitals before 1975, their offspring, and controls.
To compare the development of high-risk and control group children, and investigate which factors predicted future psychiatric disorders.
We examined information from childhood and school health record cards of 159 high-risk and 99 control group offspring. Logistic regression was used to assess whether developmental abnormalities predicted later mental disorders.
Compared with controls, children in the high-risk group had more emotional symptoms before school age, attentional problems and social inhibition at school age, and neurological soft signs throughout. In this group pre-school social adjustment problems (OR=9.7, 95% CI 1.8-51.8) or severe neurological symptoms (Fisher's test, P=0.006) predicted future schizophrenia-spectrum disorder. Social adjustment problems and emotional symptoms during school age predicted future non-psychotic psychiatric disorders.
Our study supports the validity of neurological, emotional, social and behavioural markers as vulnerability indicators of psychotic and other mental disorders, particularly among children genetically at high risk of psychosis.
赫尔辛基高危研究对1975年前在赫尔辛基精神病院接受精神分裂症谱系障碍治疗的女性、她们的后代以及对照组进行监测。
比较高危组和对照组儿童的发育情况，并调查哪些因素可预测未来的精神障碍。
我们检查了159名高危组后代和99名对照组后代的儿童期和学校健康记录卡信息。采用逻辑回归分析评估发育异常是否可预测后期精神障碍。
与对照组相比，高危组儿童在学龄前期有更多情绪症状，学龄期有注意力问题和社交抑制，且 throughout 都有神经学软体征。在该组中，学前社会适应问题（比值比=9.7，95%可信区间1.8 - 51.8）或严重神经症状（费舍尔检验，P = 0.006）可预测未来的精神分裂症谱系障碍。学龄期的社会适应问题和情绪症状可预测未来的非精神病性精神障碍。
我们的研究支持神经学、情绪、社会和行为标志物作为精神病性及其他精神障碍易感性指标的有效性，尤其是在有精神病遗传高风险的儿童中。
