Quarmby Lynne M, Parker Jeremy D K
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.
J Cell Biol. 2005 Jun 6;169(5):707-10. doi: 10.1083/jcb.200503053. Epub 2005 May 31.
A recent convergence of data indicating a relationship between cilia and proliferative diseases, such as polycystic kidney disease, has revived the long-standing enigma of the reciprocal regulatory relationship between cilia and the cell cycle. Multiple signaling pathways are localized to cilia in mammalian cells, and some proteins have been shown to act both in the cilium and in cell cycle regulation. Work from the unicellular alga Chlamydomonas is providing novel insights as to how cilia and the cell cycle are coordinately regulated.
最近一系列数据表明纤毛与增殖性疾病（如多囊肾病）之间存在关联，这重新引发了关于纤毛与细胞周期之间相互调节关系的长期谜团。多种信号通路定位于哺乳动物细胞的纤毛中，并且一些蛋白质已被证明在纤毛和细胞周期调节中都发挥作用。单细胞藻类衣藻的研究工作为纤毛和细胞周期如何协同调节提供了新的见解。
