Department of Biochemistry, Molecular Biology and Physiology, School of Medicine, University of Valladolid, Valladolid, Spain.
Unidad de Excelencia Instituto de Biología y Genética Molecular, University of Valladolid Consejo Superior de Investigaciones Científicas (CSIC), Valladolid, Spain.
Front Endocrinol (Lausanne). 2022 Jun 27;13:922825. doi: 10.3389/fendo.2022.922825. eCollection 2022.
The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signaling molecules are highly or differentially expressed in primary cilium. Rare genetic disorders that affect cilia integrity and function, such as Bardet-Biedl syndrome and Alström syndrome, have awoken interest in studying the biology of cilium. In this review, we discuss recent evidence suggesting emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic β- and α-cell functions, and its implications in regulating glucose homeostasis.
纤毛是一种位于细胞表面与细胞外环境接触的狭长细胞器。过去曾被低估，现在人们认为它能够有效地感知外部环境线索，并介导细胞间通讯，因为许多受体、离子通道和信号分子在纤毛中高度或差异表达。影响纤毛完整性和功能的罕见遗传疾病，如 Bardet-Biedl 综合征和 Alström 综合征，引起了人们对研究纤毛生物学的兴趣。在这篇综述中，我们讨论了最近的证据，这些证据表明初级纤毛和纤毛介导的信号通路在调节胰腺β细胞和α细胞功能中的新作用，以及它们在调节葡萄糖稳态中的意义。
