Swierkot Jerzy, Lewandowicz-Uszyńska Aleksandra, Jankowski Adam, Szechiński Jacek
Zakład Reumatologii Akademii Medycznej, Wrocław.
Postepy Hig Med Dosw (Online). 2005 May 25;59:219-23.
The problem of arthritis in patients with primary antibody defects is presented in this study. We describe the most common kinds of arthritis (septic, viral, and aseptic), their etiology and treatment. Other diseases characterized by a lack of immunoglobulin are also shown. The most common diseases in primary hypogammaglobulinemia, especially autoimmune disorders, are dealt with. Many disease-modifying drugs (gold, D-penicillamine, sulfasalazine, azathioprine) cause symptomatic hypogammaglobulinemia in some patients. We emphasize the role of intravenous immunoglobulin replacement therapy in the reduction of the arthritis. The possibility of immunodeficiency should be kept in mind when evaluating patients with arthritis.
本研究介绍了原发性抗体缺陷患者的关节炎问题。我们描述了最常见的关节炎类型（感染性、病毒性和无菌性）、其病因及治疗方法。还展示了其他以免疫球蛋白缺乏为特征的疾病。讨论了原发性低丙种球蛋白血症中最常见的疾病，尤其是自身免疫性疾病。许多改善病情的药物（金制剂、D-青霉胺、柳氮磺胺吡啶、硫唑嘌呤）在一些患者中会导致症状性低丙种球蛋白血症。我们强调静脉注射免疫球蛋白替代疗法在减轻关节炎方面的作用。在评估关节炎患者时应考虑免疫缺陷的可能性。
