Łaguna Paweł, Gołębiowska-Staroszczyk Sydonia, Trzaska Maciej, Grabarczyk Małgorzata, Matysiak Michał
Department of Pediatrics Hematology and Oncology, Medical University of Warsaw, Poland.
Octapharma, Poland.
Adv Clin Exp Med. 2015 Jan-Feb;24(1):153-9. doi: 10.17219/acem/28626.
Immunoglobulin preparations are one of the products of the human plasma fractionation, where the plasma is obtained, in accordance with WHO guidelines from at least 1,000 donors. These preparations contain all IgG subclasses with various antigen characteristics. In clinical practice these drugs are used as replacement therapy in patients with primary and secondary immunodeficiencies as well as immunomodulatory therapy in many autoimmune diseases and systemic inflammatory diseases. Here we present characteristics of i.v. polyvalent, human immunoglobulin preparations available on the Polish market and the possibilities of their use in clinical practice, in children with hematological diseases. Considering the very low consumption of immunoglobulin preparations in our country as compared to other European countries, we would like to draw the attention of medical professionals, especially pediatricians and haematologists, to the benefits that stem from the use of these drugs in the therapy of children with haematological diseases. Our work will also facilitate the choice of an optimal polyvalent human immunoglobulin preparation for a particular patient.
免疫球蛋白制剂是人类血浆分离制品之一，血浆是根据世界卫生组织指南从至少1000名献血者处获得的。这些制剂包含具有各种抗原特性的所有IgG亚类。在临床实践中，这些药物用作原发性和继发性免疫缺陷患者的替代疗法，以及许多自身免疫性疾病和全身性炎症性疾病的免疫调节疗法。在此，我们介绍波兰市场上可用的静脉注射多价人免疫球蛋白制剂的特性及其在血液系统疾病儿童临床实践中的使用可能性。考虑到与其他欧洲国家相比，我国免疫球蛋白制剂的消耗量非常低，我们希望引起医学专业人员，特别是儿科医生和血液学家的注意，这些药物用于治疗血液系统疾病儿童所带来的益处。我们的工作也将有助于为特定患者选择最佳的多价人免疫球蛋白制剂。
