膜联蛋白：将钙离子信号传导与膜动力学联系起来

Annexins: linking Ca2+ signalling to membrane dynamics.

作者信息

Gerke Volker, Creutz Carl E, Moss Stephen E

机构信息

Institute of Medical Biochemistry, Centre for Molecular Biology of Inflammation, University of Münster, Germany.

出版信息

Nat Rev Mol Cell Biol. 2005 Jun;6(6):449-61. doi: 10.1038/nrm1661.

DOI:10.1038/nrm1661

PMID:15928709

Abstract

Eukaryotic cells contain various Ca(2+)-effector proteins that mediate cellular responses to changes in intracellular Ca(2+) levels. A unique class of these proteins - annexins - can bind to certain membrane phospholipids in a Ca(2+)-dependent manner, providing a link between Ca(2+) signalling and membrane functions. By forming networks on the membrane surface, annexins can function as organizers of membrane domains and membrane-recruitment platforms for proteins with which they interact. These and related properties enable annexins to participate in several otherwise unrelated events that range from membrane dynamics to cell differentiation and migration.

摘要

真核细胞含有多种Ca(2+)效应蛋白，这些蛋白介导细胞对细胞内Ca(2+)水平变化的反应。其中一类独特的蛋白——膜联蛋白——可以以Ca(2+)依赖的方式与某些膜磷脂结合，在Ca(2+)信号传导和膜功能之间建立联系。通过在膜表面形成网络，膜联蛋白可以作为膜结构域的组织者和与其相互作用的蛋白质的膜招募平台。这些以及相关特性使膜联蛋白能够参与从膜动力学到细胞分化和迁移等一些原本不相关的事件。