Leskinen-Kallio S, Huovinen R, Någren K, Lehikoinen P, Ruotsalainen U, Teräs M, Joensuu H
Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland.
J Comput Assist Tomogr. 1992 May-Jun;16(3):468-74. doi: 10.1097/00004728-199205000-00023.
Quantitation of the uptake of positron emitting tracers in cancer patients is still unsettled. A uniform method is needed for comparison of results and for collecting a data base of tumor PET studies. We have measured the tumoral uptake of [11C]methionine in 46 cancer patients using four different methods of analysis. The accumulation of [11C]methionine at 35-40 min after the injection adjusted to the injected dose and body surface area turned out to give similar results as a more complicated method where the uptake rate of [11C]methionine from the plasma to the tumor was calculated (r = 0.92, p less than 0.0001). The results suggest that in clinical [11C]methionine PET studies, 40 min emission scanning with frequent blood sampling is unnecessary. Only a single 5 min emission scan 25-40 min after the injection is required for analysis if the accumulation is adjusted to the injected dose and body surface area.
癌症患者中正电子发射示踪剂摄取量的定量仍未确定。需要一种统一的方法来比较结果并收集肿瘤PET研究的数据库。我们使用四种不同的分析方法测量了46例癌症患者中[11C]蛋氨酸的肿瘤摄取情况。注射后35 - 40分钟时，将[11C]蛋氨酸的累积量根据注射剂量和体表面积进行调整，结果与计算[11C]蛋氨酸从血浆到肿瘤的摄取率这种更复杂的方法相似（r = 0.92，p < 0.0001）。结果表明，在临床[11C]蛋氨酸PET研究中，无需进行40分钟发射扫描并频繁采血。如果将累积量根据注射剂量和体表面积进行调整，仅需在注射后25 - 40分钟进行一次5分钟发射扫描即可用于分析。
