Lindholm P, Leskinen-Kallio S, Minn H, Bergman J, Haaparanta M, Lehikoinen P, Någren K, Ruotsalainen U, Teräs M, Joensuu H
Department of Oncology and Radiotherapy, Turku University Central Hospital, Finland.
J Nucl Med. 1993 Oct;34(10):1711-6.
The positron emission tomography (PET) tracer 2-18F-fluoro-2-deoxy-D-glucose (FDG) is the most widely used tracer in oncology. PET tracer. Another radiotracer, L-methyl-11C-Methionine (11C-methionine), also has been used successfully for PET imaging of brain and lung tumors, non-Hodgkin's lymphoma, breast cancer and head and neck cancer. This study compared FDG and 11C-methionine as tumor-detecting agents in head and neck cancer. Prior to cancer therapy, fourteen patients underwent a PET study with FDG and one with 11C-methionine. Nineteen of 21 malignant lesions that could be evaluated were visible with both tracers. Tracer uptake was measured as standardized uptake values (SUV) and Ki values according to Patlak et al. The mean SUV in FDG studies was 7.7 +/- 4.2 and in 11C-methionine studies 7.7 +/- 2.5, whereas the Ki values in 11C-methionine studies (mean, 0.128 +/- 0.068 min-1) were always higher than in FDG studies (mean, 0.036 +/- 0.023 min-1). A good correlation was found between the SUVs (r = 0.79, p < 0.0001) and the Ki values (r = 0.82, p < 0.001) between the two tracers. Both FDG and 11C-methionine are effective in PET imaging of head and neck cancer, and the uptake rates of the tracers seem to be closely related.
正电子发射断层扫描（PET）示踪剂2-18F-氟-2-脱氧-D-葡萄糖（FDG）是肿瘤学中使用最广泛的示踪剂。PET示踪剂。另一种放射性示踪剂L-甲基-11C-蛋氨酸（11C-蛋氨酸）也已成功用于脑和肺肿瘤、非霍奇金淋巴瘤、乳腺癌以及头颈癌的PET成像。本研究比较了FDG和11C-蛋氨酸作为头颈癌肿瘤检测剂的效果。在癌症治疗前，14例患者接受了FDG的PET研究，1例接受了11C-蛋氨酸的PET研究。在可评估的21个恶性病变中，有19个在两种示踪剂下均可见。根据帕特拉克等人的方法，将示踪剂摄取量测量为标准化摄取值（SUV）和Ki值。FDG研究中的平均SUV为7.7±4.2，11C-蛋氨酸研究中的平均SUV为7.7±2.5，而11C-蛋氨酸研究中的Ki值（平均值为0.128±0.068 min-1）始终高于FDG研究中的Ki值（平均值为0.036±0.023 min-1）。两种示踪剂的SUV（r = 0.79，p < 0.0001）和Ki值（r = 0.82，p < 0.001）之间存在良好的相关性。FDG和11C-蛋氨酸在头颈癌的PET成像中均有效，并且示踪剂的摄取率似乎密切相关。
