Yoon Kyung-Chul, Song Byoung-Yong, Seo Man-Seong
Department of Ophthalmology, Chonnam National University Medical School, Gwang-Ju, Korea.
Korean J Ophthalmol. 2005 Mar;19(1):18-22. doi: 10.3341/kjo.2005.19.1.18.
This study was performed to evaluate the changes of tear film and ocular surface caused by smoking. Symptom scoring, tear film break-up time (BUT), basal tear secretion test, corneal sensitivity test, keratoepitheliopathy scoring, and conjunctival impression cytology were performed in 29 smokers (58 eyes) and 26 non-smokers (52 eyes). Tear film BUT, basal tear secretion, corneal sensitivity, and squamous metaplasia were 7.71+/-2.66 sec, 6.29+/-2.85 mm, 53.69+/-5.69 mm, and 2.45+/-1.26 in smokers and 9.62+/-3.14 sec, 10.04+/-3.87 mm, 56.46+/-4.79 mm, and 1.12+/-0.83 in non-smokers, respectively (p<0.05). Symptom score, keratoepitheliopathy score, and goblet cell density were not significantly different between the two groups. Tear film BUT was shorter, basal tear secretion and corneal sensitivity were lower, and squamous metaplasia was higher in heavy smokers than in light smokers. In conclusion, smoking deteriorates the tear film and ocular surface with decreased quantity and quality of tear film, decreased corneal sensitivity, and squamous metaplasia, and this deterioration is related to the amount of smoking.
本研究旨在评估吸烟引起的泪膜和眼表变化。对29名吸烟者（58只眼）和26名不吸烟者（52只眼）进行了症状评分、泪膜破裂时间（BUT）、基础泪液分泌试验、角膜敏感性试验、角膜上皮病变评分和结膜印迹细胞学检查。吸烟者的泪膜BUT、基础泪液分泌、角膜敏感性和鳞状化生分别为7.71±2.66秒、6.29±2.85毫米、53.69±5.69毫米和2.45±1.26，不吸烟者分别为9.62±3.14秒、10.04±3.87毫米、56.46±4.79毫米和1.12±0.83（p<0.05）。两组之间的症状评分、角膜上皮病变评分和杯状细胞密度无显著差异。重度吸烟者的泪膜BUT较短，基础泪液分泌和角膜敏感性较低，鳞状化生程度高于轻度吸烟者。总之，吸烟会使泪膜和眼表恶化，泪膜的数量和质量下降，角膜敏感性降低，出现鳞状化生，且这种恶化与吸烟量有关。
