Bazhanova E D, Teplyi D L
Laboratory for Comparative Somnology and Neuroendocrinology, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
Neurosci Behav Physiol. 2005 May;35(4):375-8. doi: 10.1007/s11055-005-0035-z.
The aim of this study was to identify the involvement of interferon-alpha (IA) in controlling apoptosis of cells of the hypothalamo-hypophyseal-adrenocortical system (HHACS) in young and aged mice in conditions of hyperoxia. Oxidative stress led to increases in the numbers of cells synthesizing the proapoptotic protein c-fos in the paraventricular nucleus in mice of both age groups. However, the protective actions of IA in stress were more marked at the earlier stage of apoptosis in young mice. Thus, the level of involvement of IA in controlling programmed cell death of hypothalamic cells depends on the age of the animals. In the fascicular zone of the adrenals in young mice, the number of dying cells was significantly greater after administration of IA, but remained at the control level in conditions of hyperoxia alone and in combination with IA. The proportion of apoptotic cells in the adrenals of aged mice was no different from that in young mice and did not change in response to any of the treatments used.
本研究的目的是确定在高氧条件下，干扰素-α（IA）参与调控年轻和老年小鼠下丘脑-垂体-肾上腺皮质系统（HHACS）细胞凋亡的情况。氧化应激导致两个年龄组小鼠室旁核中合成促凋亡蛋白c-fos的细胞数量增加。然而，IA在应激中的保护作用在年轻小鼠凋亡的早期阶段更为显著。因此，IA参与控制下丘脑细胞程序性死亡的程度取决于动物的年龄。在年轻小鼠肾上腺束状带，给予IA后死亡细胞数量显著增加，但在单纯高氧条件下以及高氧与IA联合作用时，死亡细胞数量维持在对照水平。老年小鼠肾上腺中凋亡细胞的比例与年轻小鼠无异，且对所采用的任何处理均无变化。
