Strüder H K, Hollmann W, Donike M, Platen P, Weber K
Institut für Sportspiele, Deutsche, Sporthochschule Köln, Cologne, Germany.
Eur J Appl Physiol Occup Physiol. 1996;74(5):443-9. doi: 10.1007/BF02337725.
Neuroendrocrine and substrate responses were investigated in eight male athletes during inhalation of either 100% O2 (HE), 14% O2 (HO) or normoxio gas (NO) before, during and after 60 min of cycle ergometry at the same absolute work rate. Concentrations of prolactin (PRL), growth hormone (GH), testosterone (T), adrenocorticotropic hormone (ACTH), cortisol (COR), adrenalin (A), noradrenalin (NA), insulin (INS), ammonia (NH3), free fatty acids, serotonin (5-HT), total protein, branched-chain amino acids (BCAA) and free tryptophan (free TRP) were determined in venous blood and lactate concentration [LA-], partial pressure of oxygen (PO2), oxygen saturation (SO2), partial pressure of carbon dioxide and pH in capillary blood. The PO2 and SO2 were augmented in HE and decreased in HO (P < or = 0.01). In HO and NO no significant changes were found for any other parameter during 30 min of rest prior to exercise. In HE, PRL increased by about 400% during this time, while NA declined (P < or = 0.01). Heart rate (HR) and [LA-] were higher during exercise in HO (P < or = 0.01). In all trials, NH3, NA, A, T, GH and ACTH increased during exercise (P < or = 0.01), while BCAA and INS declined. In comparison to NO and HE, increases of NA, A, GH, COR and ACTH were higher in HO (P < or = 0.01). The PRL in NO and COR in NO and HE did not change significantly. In HE, after the initial increase at rest, PRL declined during exercise but remained higher than in HO. Higher values for NA, A, GH, COR and ACTH in HO were likely to have reflected an augmented relative exercise intensity. Our results showed that PRL but no other hormone increased during acute exposure to hyperoxia. This PRL release was independent of exercise stress and greater than PRL augmentation during hypoxia, which was related to a higher relative exercise intensity as indicated by [LA-] and HR. Responses of plasma NH3, BCAA, free TRP and 5-HT could not explain PRL augmentation induced by the increment in blood SO2 during hyperoxia.
在八名男性运动员进行60分钟相同绝对工作强度的自行车测力计运动之前、运动期间和运动之后，分别吸入100%氧气（HE）、14%氧气（HO）或正常氧气体（NO），研究其神经内分泌和底物反应。测定静脉血中催乳素（PRL）、生长激素（GH）、睾酮（T）、促肾上腺皮质激素（ACTH）、皮质醇（COR）、肾上腺素（A）、去甲肾上腺素（NA）、胰岛素（INS）、氨（NH3）、游离脂肪酸、血清素（5-HT）、总蛋白、支链氨基酸（BCAA）和游离色氨酸（游离TRP）的浓度，以及毛细血管血中的乳酸浓度[LA-]、氧分压（PO2）、氧饱和度（SO2）、二氧化碳分压和pH值。在HE组中PO2和SO2升高，在HO组中降低（P≤0.01）。在HO组和NO组中，运动前30分钟休息期间任何其他参数均未发现显著变化。在HE组中，此时PRL增加约400%，而NA下降（P≤0.01）。HO组运动期间心率（HR）和[LA-]更高（P≤0.01）。在所有试验中，运动期间NH3、NA、A、T、GH和ACTH均增加（P≤0.01），而BCAA和INS下降。与NO组和HE组相比，HO组中NA、A、GH、COR和ACTH的增加更高（P≤0.01）。NO组中的PRL以及NO组和HE组中的COR没有显著变化。在HE组中，休息时最初增加后，运动期间PRL下降，但仍高于HO组。HO组中NA、A、GH、COR和ACTH的较高值可能反映了相对运动强度的增加。我们的结果表明，急性暴露于高氧期间PRL增加，而其他激素未增加。这种PRL释放与运动应激无关，且大于低氧期间PRL的增加，低氧期间PRL的增加与[LA-]和HR所表明的较高相对运动强度有关。血浆NH3、BCAA、游离TRP和5-HT的反应无法解释高氧期间血液SO2增加所诱导的PRL增加。
