Franchini Massimo, Veneri Dino
Servizio di Immunoematologia e Trasfusione, Azienda Ospedaliera di Verona.
Recenti Prog Med. 2005 Mar;96(3):151-4.
There are increasing data on the association between Helicobacter pylori infection and idiopathic thrombocytopenic purpura and the significant increase in platelet count after bacterial eradication. The aim of this review was to consider the studies so far published on Helicobacter pylori infection and idiopathic thrombocytopenic purpura in order to evaluate a possible correlation between these two conditions. A review of the literature showed that 306 out of the 524 patients investigated (54.8%) were positive for Helicobacter pylori infection and that the bacterium was eradicated in 83% of cases. Eradication therapy was accompanied by a complete or partial platelet response in approximately half the cases. Overall, these data show that Helicobacter pylori eradication in patients with idiopathic thrombocytopenic purpura is effective in increasing platelet count. However, since the studies so far published are few, sometimes controversial and involve small series of patients, further studies on larger numbers of patients with longer followup are needed to confirm these preliminary findings.
关于幽门螺杆菌感染与特发性血小板减少性紫癜之间的关联以及细菌根除后血小板计数显著增加的数据越来越多。本综述的目的是考量迄今为止发表的关于幽门螺杆菌感染与特发性血小板减少性紫癜的研究，以评估这两种情况之间可能存在的相关性。文献综述表明，在524例接受调查的患者中，有306例（54.8%）幽门螺杆菌感染呈阳性，并且在83%的病例中该细菌被根除。根除治疗在大约一半的病例中伴随着血小板的完全或部分反应。总体而言，这些数据表明，根除特发性血小板减少性紫癜患者的幽门螺杆菌对增加血小板计数有效。然而，由于迄今为止发表的研究数量较少，有时存在争议且涉及的患者系列较小，因此需要对更多患者进行更长时间的随访研究，以证实这些初步发现。
