Gazzaruso Carmine
U.O. Medicina Interna, Presidio Ospedaliero di Sarnico, I.R.C.C.S. Fondazione Salvatore Maugeri, Pavia.
Recenti Prog Med. 2005 Mar;96(3):155-8.
Erectile dysfunction is often associated with diabetes mellitus and athero-thrombotic diseases, such as coronary heart disease, stroke, peripheral vascular disease. An association between erectile dysfunction and asymptomatic coronary artery disease angiographically verified has been recently shown in diabetic patients. Several pathophysiological mechanisms may explain the relationship between erectile dysfunction and athero-thrombosis, especially in diabetic subjects. Among these mechanisms, it is of interest to consider a common pattern of cardiovascular risk factors, the presence of autonomic neuropathy and endothelial dysfunction. The strong association between erectile dysfunction and athero-thrombosis may have some important clinical implications. In particular, erectile dysfunction may be used as a predictor of silent or early athero-thrombotic diseases, especially in diabetic patients.
勃起功能障碍常与糖尿病及动脉粥样硬化血栓形成性疾病相关，如冠心病、中风、外周血管疾病。最近在糖尿病患者中发现，勃起功能障碍与经血管造影证实的无症状冠状动脉疾病之间存在关联。几种病理生理机制可以解释勃起功能障碍与动脉粥样硬化血栓形成之间的关系，尤其是在糖尿病患者中。在这些机制中，考虑心血管危险因素的共同模式、自主神经病变和内皮功能障碍的存在是很有意义的。勃起功能障碍与动脉粥样硬化血栓形成之间的密切关联可能具有一些重要的临床意义。特别是，勃起功能障碍可作为隐匿性或早期动脉粥样硬化血栓形成性疾病的预测指标，尤其是在糖尿病患者中。
