Sachan Dileep S, Hongu Nobuko, Johnsen Maike
Nutrition Department, University of Tennessee, Knoxville, TN 37996-1920, USA.
J Am Coll Nutr. 2005 Jun;24(3):172-6. doi: 10.1080/07315724.2005.10719462.
Fatty acid oxidation is predominantly a mitochondrial event, which is enhanced by dietary choline and carnitine supplementation resulting in extra reactive oxygen species (ROS) load. The objective was to assess oxidative stress level by thiobarbituric acid reactive substances [TBARS] in choline and carnitine supplemented healthy women before and after mild exercise.
Nineteen free-living women completed the placebo control study in which choline and/or L-carnitine was orally taken for 21 days. Anthropometric measurements, dietary recall, exercise routine and blood samples were analyzed to determine body composition, nutrients intake, distance walked and biochemical markers related to oxidative stress.
TBARS were significantly lower in the groups supplemented with choline, carnitine or both and the mild exercise (walking) was not a deterrent in this effect of the supplements. Serum vitamin A and E concentrations were higher in the supplemented groups even though the consumption of these nutrients was not different among the groups.
Choline and carnitine supplementation lowers lipid peroxidation, and promotes conservation of retinol and alpha-tocopherol in free-living women.
脂肪酸氧化主要发生在线粒体中，膳食补充胆碱和肉碱可增强该过程，从而导致额外的活性氧（ROS）负荷。本研究旨在通过硫代巴比妥酸反应性物质（TBARS）评估轻度运动前后补充胆碱和肉碱的健康女性的氧化应激水平。
19名自由生活的女性完成了安慰剂对照研究，她们口服胆碱和/或左旋肉碱21天。分析人体测量数据、饮食回忆、运动习惯和血样，以确定身体成分、营养摄入、步行距离以及与氧化应激相关的生化指标。
补充胆碱、肉碱或两者的组中TBARS显著降低，轻度运动（步行）并未影响这些补充剂的这种作用。补充组的血清维生素A和E浓度较高，尽管各组之间这些营养素的摄入量并无差异。
补充胆碱和肉碱可降低脂质过氧化，并促进自由生活女性体内视黄醇和α-生育酚的保存。
