Saito Mitsuru, Fujii Katsuyuki
Department of Orthopaedic Surgery, Jikei University School of Medicine, Tokyo, Japan.
Clin Calcium. 2005 Jun;15(6):939-45.
Little is known about the correlation between degree of mineralization and collagen properties (enzymatic and non-enzymatic cross-links) in bone. In the patients with femoral neck fracture, not only the mineral embrittlement but also the qualitative changes in collagen cross-links were observed in both low and high mineralized bone fractions. These results suggest that this trend towards an increased loss of collagen quality may have led to accelerated increase of fragility in osteoporosis.
关于骨矿化程度与胶原蛋白特性（酶促和非酶促交联）之间的相关性，人们所知甚少。在股骨颈骨折患者中，在低矿化和高矿化骨部分均观察到不仅有矿物质脆化，还有胶原蛋白交联的质性变化。这些结果表明，这种胶原蛋白质量损失增加的趋势可能导致骨质疏松症中脆性的加速增加。
