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Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-butyl-3-substituted quinazolin-4-(3H)-ones.

作者信息

Alagarsamy Veerachamy, Rajasolomon Viswas, Meena Ramseshu, Ramseshu Kona Venkat

机构信息

Medicinal Chemistry Laboratory, Periyar College of Pharmaceutical Sciences for Girls, Trichy, India.

出版信息

Biol Pharm Bull. 2005 Jun;28(6):1091-4. doi: 10.1248/bpb.28.1091.

DOI:10.1248/bpb.28.1091
PMID:15930752
Abstract

A variety of novel 2-butyl-3-substituted quinazolin-4-(3H)-ones have been synthesized by reacting (2-butyl-4-oxo-3H-quinazolin-3-yl)dithiocarbamic acid methyl ester with a variety of amines; the starting material dithiocarbamate was synthesized from anthranilic acid. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. While the test compounds exhibited significant activity, compounds A1, A2, A3 and A4 showed more potent analgesic activity and compound A4 showed more potent anti-inflammatory activity than the reference diclofenac sodium.

摘要

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