• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones.

作者信息

Alagarsamy Veerachamy, Salomon Viswas Raja, Vanikavitha Gnanavel, Paluchamy Veeran, Chandran Muniyandi Ravi, Sujin Augustin Arnald, Thangathiruppathy Arunachalam, Amuthalakshmi Sivaperuman, Revathi Rajappan

机构信息

Medicinal Chemistry Laboratory, SB College of Pharmacy, Sivakasi, India.

出版信息

Biol Pharm Bull. 2002 Nov;25(11):1432-5. doi: 10.1248/bpb.25.1432.

DOI:10.1248/bpb.25.1432
PMID:12419954
Abstract

A series of novel 2-phenyl-3-substituted quinazolin-4(3H)-ones have been synthesized by treating methyl-N-(2-phenyl quinazolin-3-yl-4(3H)-one) dithiocarbamate with different amines, the starting material dithiocarbamate was synthesized from anthranilic acid. The title compounds were investigated for analgesic, anti-inflammatory and antibacterial activities. All the test compounds exhibited significant activity, the compounds A1, A2 and A3 shown more potent analgesic activity, and the compound A3 shown more potent anti-inflammatory activity than the reference standard diclofenac sodium.

摘要

相似文献

1
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-phenyl-3-substituted quinazolin-4(3H) ones.
Biol Pharm Bull. 2002 Nov;25(11):1432-5. doi: 10.1248/bpb.25.1432.
2
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-butyl-3-substituted quinazolin-4-(3H)-ones.
Biol Pharm Bull. 2005 Jun;28(6):1091-4. doi: 10.1248/bpb.28.1091.
3
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methylthio-3-substituted quinazolin-4-(3H)-ones.
Biol Pharm Bull. 2004 May;27(5):652-6. doi: 10.1248/bpb.27.652.
4
Synthesis, analgesic and anti-inflammatory activities of some novel 2,3-disubstituted quinazolin-4(3H)-ones.一些新型2,3-二取代喹唑啉-4(3H)-酮的合成、镇痛及抗炎活性
Biol Pharm Bull. 2003 Apr;26(4):557-9. doi: 10.1248/bpb.26.557.
5
Synthesis, analgesic, anti-inflammatory and antibacterial activities of some novel 2-methyl-3-substituted quinazolin-4-(3H)-ones.一些新型2-甲基-3-取代喹唑啉-4-（3H）-酮的合成、镇痛、抗炎和抗菌活性
Biol Pharm Bull. 2003 Dec;26(12):1711-4. doi: 10.1248/bpb.26.1711.
6
Synthesis and evaluation of novel 2-substituted-quinazolin-4(3H)-ones as potent analgesic and anti-inflammatory agents.新型 2-取代-4(3H)-喹唑啉酮的合成与评价及其作为潜在的镇痛抗炎药物。
Arch Pharm (Weinheim). 2010 Feb;343(2):108-13. doi: 10.1002/ardp.200900231.
7
Synthesis, analgesic, anti-inflammatory, ulcerogenic index and antibacterial activities of novel 2-methylthio-3-substituted-5,6,7,8-tetrahydrobenzo (b) thieno[2,3-d]pyrimidin-4(3H)-ones.新型2-甲硫基-3-取代-5,6,7,8-四氢苯并(b)噻吩并[2,3-d]嘧啶-4(3H)-酮的合成、镇痛、抗炎、致溃疡指数及抗菌活性
Eur J Med Chem. 2006 Nov;41(11):1293-300. doi: 10.1016/j.ejmech.2006.06.005. Epub 2006 Aug 22.
8
Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.某些3-(4-甲基苯基)-2-取代氨基-3H-喹唑啉-4-酮作为镇痛和抗炎剂的合成及药理学评价
Arch Pharm (Weinheim). 2007 Jan;340(1):41-6. doi: 10.1002/ardp.200600189.
9
3-(3-ethylphenyl)-2-substituted hydrazino-3H-quinazolin-4-one derivatives: new class of analgesic and anti-inflammatory agents.3-(3-乙基苯基)-2-取代肼基-3H-喹唑啉-4-酮衍生物：新型镇痛和抗炎药
Chem Biol Drug Des. 2009 Apr;73(4):471-9. doi: 10.1111/j.1747-0285.2009.00794.x.
10
Synthesis and pharmacological evaluation of some 3-(2-methylphenyl)-2-substituted amino-quinazolin-4(3H)-ones as analgesic and antiinflammatory agents.某些3-(2-甲基苯基)-2-取代氨基喹唑啉-4(3H)-酮作为镇痛和抗炎剂的合成及药理评价
Arzneimittelforschung. 2008;58(4):174-81. doi: 10.1055/s-0031-1296489.

引用本文的文献

1
Synthesis and antihypertensive screening of new derivatives of quinazolines linked with isoxazole.与异恶唑相连的喹唑啉新衍生物的合成及降压活性筛选
Biomed Res Int. 2014;2014:739056. doi: 10.1155/2014/739056. Epub 2014 Jun 12.
2
Biological effects of a new set 1,2,4-triazolo[1,5-a]quinazolines on heart rate and blood pressure.新型1,2,4-三唑并[1,5-a]喹唑啉类化合物对心率和血压的生物学效应。
Chem Cent J. 2014 Jan 15;8(1):3. doi: 10.1186/1752-153X-8-3.
3
Quinazoline derivatives: synthesis and bioactivities.喹唑啉衍生物：合成与生物活性。
Chem Cent J. 2013 Jun 3;7(1):95. doi: 10.1186/1752-153X-7-95.
4
Synthesis and anti-microbial screening of novel schiff bases of 3-amino-2-methyl quinazolin 4-(3H)-one.新型3-氨基-2-甲基喹唑啉-4-(3H)-酮席夫碱的合成与抗菌筛选
J Adv Pharm Technol Res. 2010 Jul;1(3):320-5. doi: 10.4103/0110-5558.72426.
5
Anticonvulsant Activity of Schiff Bases of 3-Amino-6,8-dibromo-2-phenyl-quinazolin-4(3H)-ones.3-氨基-6,8-二溴-2-苯基喹唑啉-4(3H)-酮席夫碱的抗惊厥活性
Indian J Pharm Sci. 2010 May;72(3):375-8. doi: 10.4103/0250-474X.70488.
6
Antibacterial activity of some 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones: synthesis and preliminary QSAR studies.某些3-（亚芳基氨基）-2-苯基喹唑啉-4（3H）-酮的抗菌活性：合成及初步定量构效关系研究
Molecules. 2007 Oct 30;12(10):2413-26. doi: 10.3390/12102413.