优雅小克银汉霉对白杨素和芹菜素的生物转化

Biotransformation of chrysin and apigenin by Cunninghamella elegans.

作者信息

Ibrahim Abdel-Rahim Sayed

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta 8130, Egypt.

出版信息

Chem Pharm Bull (Tokyo). 2005 Jun;53(6):671-3. doi: 10.1248/cpb.53.671.

DOI:10.1248/cpb.53.671

PMID:15930780

Abstract

Biotransformation of chrysin by Cunninghamella elegans NRRL 1392 produced apigenin, apigenin 7-sulfate, apigenin 7,4'-disulfate, and a new metabolite identified as chrysin 7-sulfate. On the other hand, fermentation of apigenin, using the same microorganism, yielded apigenin 7-sulfate and apigenin 7,4'-disulfate. The structures of the metabolites were established by spectral analysis, and acid and enzyme hydrolyses in addition to comparison with reference samples.

摘要

雅致小克银汉霉NRRL 1392对白杨素的生物转化产生了芹菜素、芹菜素7-硫酸盐、芹菜素7,4'-二硫酸盐，以及一种鉴定为白杨素7-硫酸盐的新代谢产物。另一方面，使用相同的微生物对芹菜素进行发酵，得到了芹菜素7-硫酸盐和芹菜素7,4'-二硫酸盐。代谢产物的结构通过光谱分析、酸和酶水解以及与参考样品比较得以确定。