Naumova L A, Paltsev A I, Beliaeva Ia Iu
Eksp Klin Gastroenterol. 2005(2):22-8.
A clinical and endoscopic examination and morphological study of gastrobiopsies were conducted in 62 patients with Helicobacter (H.) pylori-negative and -positive chronic atrophic gastritis (CAG) to study the manifestations of the atrophic process in the mucous coat of the stomach (MCS) and stages of its progression in terms of pre-cancerous changes (second stage). The MCS atrophy is characterized by considerable frequency of concomitant endocrinopathies, connective tissue dysplasia, systemic lesions of the mucous coats of the gastrointestinal tract, as well as morphologically diverse disorders of proliferation and differentiation. Thus, the MCS atrophy appears as a result of homeostasis dysregulation at various levels. CAG being a particular manifestation of the atrophy phenomenon characterized by polyetiology and complexity of pathogenesis cannot be reduced to one causal factor (HP), and therefore it deserves special attention and needs further study.
对62例幽门螺杆菌（H. pylori）阴性和阳性的慢性萎缩性胃炎（CAG）患者进行了临床、内镜检查及胃活检的形态学研究，以探讨胃黏膜层（MCS）萎缩过程的表现及其在癌前病变（第二阶段）方面的进展阶段。MCS萎缩的特征是伴随内分泌病、结缔组织发育异常、胃肠道黏膜层的系统性病变的频率相当高，以及增殖和分化方面形态多样的紊乱。因此，MCS萎缩是不同水平稳态调节失衡的结果。CAG作为萎缩现象的一种特殊表现，具有多病因和发病机制的复杂性，不能归结于一个因果因素（幽门螺杆菌），因此值得特别关注并需要进一步研究。
