[Particular features of clinical and morphological manifestations of the atrophic process in the mucous coat of the stomach in case of absence and presence of infection with Helicobacter pylori (first stage)].

A clinical and endoscopic examination and morphological study of gastrobiopsies were conducted in 62 patients with Helicobacter (H.) pylori-negative and -positive chronic atrophic gastritis (CAG) to study the manifestations of the atrophic process in the mucous coat of the stomach (MCS) and stages of its progression in terms of pre-cancerous changes (second stage). The MCS atrophy is characterized by considerable frequency of concomitant endocrinopathies, connective tissue dysplasia, systemic lesions of the mucous coats of the gastrointestinal tract, as well as morphologically diverse disorders of proliferation and differentiation. Thus, the MCS atrophy appears as a result of homeostasis dysregulation at various levels. CAG being a particular manifestation of the atrophy phenomenon characterized by polyetiology and complexity of pathogenesis cannot be reduced to one causal factor (HP), and therefore it deserves special attention and needs further study.