Zhu Shou-Fei, Yang Yun, Wang Li-Xin, Liu Bin, Zhou Qi-Lin
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Org Lett. 2005 Jun 9;7(12):2333-5. doi: 10.1021/ol050556x.
[reaction: see text] A novel chiral monodentate spiro phenylphospholane ligand 4 was prepared from a readily accessible, enantiomerically pure 1,1'-spirobiindane-7,7'-diol in high yield. This ligand has proven to be efficient for Pd-catalyzed enantioselective allylation of aldehydes with allylic alcohols. Aromatic, heteroaromatic, and aliphatic aldehydes gave homoallylic alcohols in good enantioselectivities (up to 83% ee) and excellent anti diastereoselectivities (up to 99:1 dr).
[反应：见正文] 一种新型手性单齿螺环苯基膦烷配体4由易于获得的对映体纯的1,1'-螺二氢茚-7,7'-二醇高产率制备而成。该配体已被证明在钯催化的醛与烯丙醇的对映选择性烯丙基化反应中是有效的。芳香醛、杂芳醛和脂肪醛能以良好的对映选择性（高达83% ee）和优异的非对映选择性（高达99:1 dr）生成高烯丙醇。
