黑种草碱和氢溴酸黑种草胺的全合成。

Total synthesis of nigellicine and nigeglanine hydrobromide.

作者信息

Elliott Eric L, Bushell Simon M, Cavero Marta, Tolan Brian, Kelly T Ross

机构信息

E. F. Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA.

出版信息

Org Lett. 2005 Jun 9;7(12):2449-51. doi: 10.1021/ol050769m.

DOI:10.1021/ol050769m

PMID:15932220

Abstract

[reaction: see text] The first syntheses of the pyridazinoindazolium alkaloids nigellicine and nigeglanine hydrobromide via a common intermediate are described. Ortho-lithiation/acylation and the direct amination of an isatin ring system are the key steps in the synthesis.

摘要

[反应：见正文] 描述了通过一个共同中间体首次合成哒嗪并吲唑生物碱黑种草碱和氢溴酸黑种草宁碱。异吲哚酮环系的邻位锂化/酰化反应以及直接胺化反应是合成中的关键步骤。