稠合吲唑环系统的合成及其在盐酸去甲血根碱中的应用。
Synthesis of fused indazole ring systems and application to nigeglanine hydrobromide.
机构信息
The Scripps Research Institute Mail MB-26, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
出版信息
Org Lett. 2012 Mar 16;14(6):1600-3. doi: 10.1021/ol300303s. Epub 2012 Mar 2.
Abstract
The single-step synthesis of fused tricyclic pyridazino[1,2-a]indazolium ring systems is described. Structural details revealed by crystallography explain the unexpected reactivity. The method is applied to the gram scale synthesis of nigeglanine hydrobromide.
摘要
描述了融合的三环吡啶并[1,2-a]吲唑鎓环系统的单步合成。晶体学揭示的结构细节解释了这种出乎意料的反应性。该方法被应用于nigeglanine 氢溴酸盐的克级合成。
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