Hwang Woo Suk, Lee Byeong Chun, Lee Chang Kyu, Kang Sung Keun
Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
J Vet Sci. 2005 Jun;6(2):87-96.
The remarkable potential of embryonic stem (ES) cells is their ability to develop into many different cell types. ES cells make it possible to treat patients by transplanting specialized healthy cells derived from them to repair damaged and diseased cells or tissues, known as "stem cell therapy". However, the issue of immunocompatibility is one of considerable significance in ES cell transplantation. One approach to overcome transplant rejection of human ES (hES) cells is to derive hES cells from nuclear transfer of the patient's own cells. This concept is known as "therapeutic cloning". In this review, we describe the derivations of ES cells and cloned ES cells by somatic cell nuclear transfer, and their potential applications in transplantation medicine.
胚胎干细胞（ES细胞）的显著潜能在于其能够发育成多种不同的细胞类型。通过移植源自ES细胞的特化健康细胞来修复受损和患病的细胞或组织，即“干细胞疗法”，这使得治疗患者成为可能。然而，免疫相容性问题在ES细胞移植中具有相当重要的意义。克服人ES（hES）细胞移植排斥的一种方法是通过患者自身细胞的核移植来获得hES细胞。这一概念被称为“治疗性克隆”。在本综述中，我们描述了通过体细胞核移植获得ES细胞和克隆ES细胞的方法，以及它们在移植医学中的潜在应用。
