Comenzo R L, Malachowski M E, Meissner H C, Fulton D R, Berkman E M
Department of Medicine, New England Medical Center, Boston.
J Pediatr. 1992 Jun;120(6):926-8. doi: 10.1016/s0022-3476(05)81964-x.
One week after treatment with intravenously administered immune globulin and aspirin, a child with Kawasaki disease had persistent fever and an increase in coronary artery diameter to greater than 3 mm. Two additional doses of immune globulin were given intravenously. Rapid hemolysis occurred, followed by disseminated intravascular coagulation and serum sickness. Clinicians should be aware that immune globulin preparations contain antibodies to blood-type antigens that may cause significant hemolysis and disseminated intravascular coagulation.
在接受静脉注射免疫球蛋白和阿司匹林治疗一周后，一名川崎病患儿仍持续发热，冠状动脉直径增加至大于3毫米。又静脉注射了两剂免疫球蛋白。随后迅速发生溶血，继之出现弥散性血管内凝血和血清病。临床医生应意识到免疫球蛋白制剂含有针对血型抗原的抗体，可能会导致严重溶血和弥散性血管内凝血。
