Woodman Ciaran B J, Collins Stuart I, Vavrusova Nicol, Rao Ankit, Middeldorp Jaap M, Kolar Zdenek, Kumari Angela, Nelson Paul, Young Lawrence S, Murray Paul G
Cancer Research UK Institute for Cancer Studies, University of Birmingham.
Pediatr Infect Dis J. 2005 Jun;24(6):498-502. doi: 10.1097/01.inf.0000164709.40358.b6.
The natural history of Epstein-Barr virus (EBV) infection is poorly defined. We report the prevalence and subsequent incidence of EBV infection in a cohort of sexually active young women and explore the social and sexual determinants of incident infections.
The study population was drawn from a cohort of young women, who were recruited for a longitudinal study of risk factors for early cervical neoplasia. A case-control analysis, nested within the cohort of 45 women for whom the first EBV sample tested was EBV-negative and who had further follow-up, was undertaken. EBV serostatus was determined in serum with a synthetic peptide-based enzyme-linked immunosorbent assay; EBV DNA was measured in cervical smears with the use of quantitative polymerase chain reaction.
Of 1023 women 15-19 years of age included in this analysis, 978 (95.6%) tested positive for antibodies to EBV in their first serum sample. Of 45 women who tested negative, 22 subsequently acquired an asymptomatic EBV infection; the median time to seroconversion was 25 months (range, 1-60 months), and the median age at seroconversion was 18 years (range, 16-21 years). The risk of seroconversion increased with increasing number of sexual partners [compared with 1 partner, odds ratio (OR) was 1.28 for 2 partners and 2.23 for 3 or more; chiTREND 5.02; df 1; P < 0.05] and was greatest when a new sexual partner had been acquired in the 2 years before seroconversion (OR 4.78; chi 4.62; df 1; P < 0.05). EBV DNA was detected in 9 of 14 women who seroconverted and who also provided cervical samples.
In susceptible young women, the acquisition of EBV infection is associated with their sexual behavior.
爱泼斯坦-巴尔病毒（EBV）感染的自然史尚不明确。我们报告了一群性活跃年轻女性中EBV感染的患病率及后续发病率，并探讨了新发感染的社会和性决定因素。
研究人群来自一群年轻女性，她们被招募来进行早期宫颈肿瘤形成危险因素的纵向研究。在45名首次检测的EBV样本为EBV阴性且有进一步随访的女性队列中进行了病例对照分析。用基于合成肽的酶联免疫吸附测定法测定血清中的EBV血清学状态；用定量聚合酶链反应测定宫颈涂片中的EBV DNA。
在本次分析纳入的1023名15至19岁女性中，978名（95.6%）首次血清样本中EBV抗体检测呈阳性。在45名检测为阴性的女性中，22名随后获得了无症状EBV感染；血清转化的中位时间为25个月（范围1至60个月），血清转化时的中位年龄为18岁（范围16至21岁）。血清转化风险随性伴侣数量增加而升高[与1名伴侣相比，2名伴侣的比值比（OR）为1.28，3名或更多伴侣为2.23；趋势检验χ² = 5.02；自由度1；P < 0.05]，且在血清转化前2年内获得新性伴侣时风险最高（OR 4.78；χ² = 4.62；自由度1；P < 0.05）。在14名血清转化且提供了宫颈样本的女性中，9名检测到EBV DNA。
在易感年轻女性中，EBV感染的获得与其性行为有关。
