Andersson-Ellström A, Bergström T, Svennerholm B, Milsom I
Centre for Public Health Research and the District Health Care Centre, Gripen, Karlstad, Sweden.
Acta Obstet Gynecol Scand. 1997 Sep;76(8):779-83. doi: 10.3109/00016349709024347.
To: (i) evaluate longitudinally the prevalence of Epstein-Barr virus (EBV) DNA in the cervix of healthy teenage girls, (ii) relate the presence of cervical EBV DNA to virginity or sexual experience, and (iii) relate the occurrence of cervical EBV DNA to the presence of specific IgG antibodies to EBV virus capsid antigen (EBV-VCA) in serum and to signs of genital infection.
Thirty-six teenage girls were followed for 2 years between the ages of 16 and 18 years. A sexual history was taken and a gynecological examination was performed on each occasion. The presence of EBV DNA in the cervix and of EBV VCA antibodies in serum was determined on each occasion.
Coitus debut was reported by 23/36 girls (64%) and by 31/36 (86%) at 16- and 18-years of age, respectively. Two girls (only one with sexual debut) harbored EBV DNA in the cervix at 16 years of age. At the age of 18, no EBV DNA was found in these two girls, but another three girls carried EBV DNA in the cervix. All were sexually active and reported 1, 4 and 7 life-time sexual partners respectively. Serum EBV-VCA antibodies were found in 83% of the 16-year old girls and in 89% of the 18-year old girls (no significant difference between sexually experienced and virginal girls at either age). All the girls with cervical EBV DNA had antibodies against EBV-VCA. None of the girls with EBV DNA were found to carry HPV DNA or have a chlamydial infection in the cervix at any time during the study. There was no significant difference in the number of girls with a cervix secretion predominated by leucocytes between girls with positive and negative cervical EBV DNA samples.
We conclude that among these healthy teenage girls the non-sexual route of transmission of EBV is more plausible than the sexual one.
(i) 纵向评估健康少女宫颈中爱泼斯坦-巴尔病毒（EBV）DNA的流行情况；(ii) 将宫颈EBV DNA的存在与处女膜完整性或性经历相关联；(iii) 将宫颈EBV DNA的出现与血清中针对EBV病毒衣壳抗原（EBV-VCA）的特异性IgG抗体的存在以及生殖器感染迹象相关联。
36名少女在16至18岁之间接受了为期2年的随访。每次均采集性病史并进行妇科检查。每次均测定宫颈中EBV DNA的存在情况以及血清中EBV VCA抗体的存在情况。
23/36名女孩（64%）报告了首次性交，在16岁和18岁时分别为31/36名（86%）女孩报告了首次性交。两名女孩（只有一名有首次性交经历）在16岁时宫颈中携带EBV DNA。在18岁时，这两名女孩中未发现EBV DNA，但另外三名女孩宫颈中携带EBV DNA。所有这些女孩都有性活动，分别报告有1、4和7个性伴侣。在16岁女孩中有83%以及18岁女孩中有89%检测到血清EBV-VCA抗体（在这两个年龄段，有性经历的女孩和处女之间无显著差异）。所有宫颈中有EBV DNA的女孩都有针对EBV-VCA的抗体。在研究期间的任何时候，未发现任何携带EBV DNA的女孩宫颈中携带HPV DNA或患有衣原体感染。宫颈EBV DNA样本呈阳性和阴性的女孩之间，以白细胞为主的宫颈分泌物女孩数量无显著差异。
我们得出结论，在这些健康少女中，EBV的非性传播途径比性传播途径更具合理性。
