Farin E
Universitätsklinikum Freiburg, Abt. Qualitätsmanagement und Sozialmedizin, Breisacherstrasse 62, Haus 4, 79106 Freiburg, Germany.
Rehabilitation (Stuttg). 2005 Jun;44(3):157-64. doi: 10.1055/s-2004-834785.
For a fair comparison of rehabilitation centres with respect to the effects of the treatment provided (e. g. for the purpose of quality assurance programmes), it is essential that those factors which influence the outcome of rehabilitation treatment and over which the rehabilitation centres have no control (the so-called "confounders", such as co-morbidity and age of the patients on commencement of treatment) are included in the statistical analysis. Simple linear regression models without random effects and without interaction terms are frequently used for this purpose. However, this method has certain limitations which can be avoided if hierarchical linear modelling (HLM) is employed. HLM has the advantage over standard regression analysis methods in that it can be used to take into account the multi-level structure of a comparison problem, allows predictors to be introduced at the level of the centres and also makes it possible to model variations of regression coefficients for the centres. When the HLM technique is used, separate linear models can be produced for the various hierarchically structured data levels of the question (e. g. the levels "patients" and "centres" for rehabilitation centres, for example). Moreover, it can be empirically tested with HLMs whether the rehabilitation coefficients (e. g. effects of mean age of patients on the outcome of rehabilitation) differ significantly between the centres. In this article, we describe the use of hierarchical linear modelling on the basis of data obtained from the quality assurance programme of the statutory health insurance schemes in the field of medical rehabilitation ("QS-Reha").
为了公平比较康复中心所提供治疗的效果(例如用于质量保证计划),至关重要的是,那些影响康复治疗结果且康复中心无法控制的因素(即所谓的“混杂因素”,如治疗开始时患者的合并症和年龄)应纳入统计分析。为此,常使用无随机效应且无交互项的简单线性回归模型。然而,这种方法存在一定局限性,若采用分层线性建模(HLM)则可避免这些局限。HLM相较于标准回归分析方法具有优势,因为它可用于考虑比较问题的多层次结构,允许在中心层面引入预测变量,还能对中心的回归系数变化进行建模。使用HLM技术时,可为问题的各个层次结构数据水平(例如康复中心的“患者”和“中心”层面)生成单独的线性模型。此外,通过HLM可以实证检验康复系数(例如患者平均年龄对康复结果的影响)在各中心之间是否存在显著差异。在本文中,我们基于从医疗康复领域法定健康保险计划的质量保证计划(“QS - Reha”)获得的数据,描述分层线性建模的应用。