Nostro A, Cellini L, Di Bartolomeo S, Di Campli E, Grande R, Cannatelli M A, Marzio L, Alonzo V
Pharmaco-Biological Department, University of Messina, Messina, Italy.
Phytother Res. 2005 Mar;19(3):198-202. doi: 10.1002/ptr.1640.
The aim of this work was to evaluate the antibacterial effect of plant extracts as alternative and[sol ]or as active agents supporting antibiotics for treating Helicobacter pylori infection. The effect of either, ethanolic or aqueous extracts from 17 plant materials were studied against one H. pylori standard strain and 11 clinical isolates using a disc diffusion test and by evaluating the minimum inhibitory concentration (MIC) on solid media. An inhibitory activity against H. pylori strains was recorded in a large percentage of tested plants. MIC values of ethanolic extracts were from two to four concentration steps lower than the aqueous ones. In particular, ethanolic extracts of Cuminum cyminum L. and Propolis expressed MIC90 values of 0.075 mg/mL. The results show a significant in vitro effect of plant extracts against H. pylori that could be considered a valuable support in the treatment of the infection and may contribute to the development of new and safe agents for inclusion in anti-H. pylori regimens.
这项工作的目的是评估植物提取物作为替代物和/或作为支持抗生素治疗幽门螺杆菌感染的活性剂的抗菌效果。使用纸片扩散法并通过评估固体培养基上的最低抑菌浓度（MIC），研究了17种植物材料的乙醇提取物或水提取物对1株幽门螺杆菌标准菌株和11株临床分离株的作用。在很大比例的受试植物中记录到了对幽门螺杆菌菌株的抑制活性。乙醇提取物的MIC值比水提取物低两到四个浓度级别。特别是，孜然芹和蜂胶的乙醇提取物的MIC90值为0.075mg/mL。结果表明植物提取物对幽门螺杆菌具有显著的体外作用，这可被视为治疗该感染的有价值的支持，并且可能有助于开发新的安全药物以纳入抗幽门螺杆菌治疗方案。
