[CLONGAMMA治疗变应性鼻炎的疗效观察]

[Survey of the therapeutic reactions of CLONGAMMA in allergic rhinitis].

作者信息

Liu Guanghui, Zhu Rongfei, Li Wenjing, Wang Zhongxi, Huang Aixia, Chen Huan, Zhang Wei

机构信息

Allergy Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

出版信息

Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2005 Mar;19(5):205-6.

PMID:15934285

Abstract

OBJECTIVE

To evaluate the efficacy of IFN-gamma for treatment of allergic rhinitis.

METHOD

Sixty patients studied were divided into 2 groups randomly. The control group was given specific immunotherapy, the observe group was given specific immunotherapy and IFN-gamma treatment (1000000 IU im qod). Symptom score and level of serum IL-4 and ECP were compared pre and post treatment in two groups after 6 month.

RESULT

In control group, the symptom score were 10.6 +/- 2.3 and 4.2 +/- 1.8 pre and post therapy, IL-4 were (545.3 +/- 86.2) ng/L and (320.4: +/- 76.3) ng/L, ECP were (24.3 +/- 8.2) microg/L and (12.4 +/- 6.3) microg/L. In observe group, the symptom score were 10.8 +/- 2.7 and 3.5 +/- 1.6 pre and post therapy, IL-4 were (547.8 +/- 84.6) ng/L and (280.4 +/- 87.3) ng/L, ECP were (25.1 +/- 7.7) microg/L and (10.4 +/- 5.1) microg/L. All the data P < 0.05. And after the therapy, there were significant difference in the observe group and the control group.

CONCLUSION

IFN-gamma may modulate the immune system and was effective in the treatment for allergic rhinitis.

摘要

目的

评估γ干扰素治疗变应性鼻炎的疗效。

方法

将60例研究对象随机分为2组。对照组给予特异性免疫疗法，观察组给予特异性免疫疗法及γ干扰素治疗（1000000国际单位，肌肉注射，隔日1次）。6个月后比较两组治疗前后的症状评分、血清白细胞介素-4（IL-4）水平及嗜酸性粒细胞阳离子蛋白（ECP）水平。

结果

对照组治疗前、后的症状评分为10.6±2.3和4.2±1.8，IL-4分别为（545.3±86.2）纳克/升和（320.4±76.3）纳克/升，ECP分别为（24.3±8.2）微克/升和（12.4±6.3）微克/升。观察组治疗前、后的症状评分为10.8±2.7和3.5±1.6，IL-4分别为（547.8±84.6）纳克/升和（280.4±87.3）纳克/升，ECP分别为（25.1±7.7）微克/升和（10.4±5.1）微克/升。所有数据P<0.05。治疗后，观察组与对照组之间存在显著差异。