Kang Yibin
Princeton University Department of Molecular Biology, Princeton, NJ 08544, USA.
Expert Rev Mol Diagn. 2005 May;5(3):385-95. doi: 10.1586/14737159.5.3.385.
Metastasis, the spread of cancer from primary tumors to distant vital organs, has devastating consequences. Lack of effective tools to study this complex problem has hindered the development of accurate prognostic methods and effective treatments for metastatic cancer. In the postgenomic era, the application of genomic profiling methods to the analysis of clinical metastasis samples and animal metastasis models has revolutionized the field of metastasis research. This article reviews recent breakthroughs in the functional genomic analysis of metastasis. In addition, its impacts on our understanding of the molecular basis of metastasis and on clinical practice are discussed.
转移，即癌症从原发肿瘤扩散至远处重要器官，会产生毁灭性后果。缺乏研究这一复杂问题的有效工具阻碍了转移性癌症准确预后方法和有效治疗手段的发展。在后基因组时代，基因组分析方法在临床转移样本及动物转移模型分析中的应用彻底改变了转移研究领域。本文综述了转移功能基因组分析方面的最新突破。此外，还讨论了其对我们理解转移分子基础及临床实践的影响。
