乳腺癌转移中的信号通路——功能基因组学的新见解。
Signaling pathways in breast cancer metastasis - novel insights from functional genomics.
机构信息
Department of Molecular Biology, Washington Road, LTL 255, Princeton University, Princeton, NJ 08544, USA.
出版信息
Breast Cancer Res. 2011 Mar 14;13(2):206. doi: 10.1186/bcr2831.
Abstract
The advent of genomic profiling technology has brought about revolutionary changes in our understanding of breast cancer metastasis. Gene expression analyses of primary tumors have been used to predict metastatic propensity with high accuracy. Animal models of metastasis additionally offer a platform to experimentally dissect components of the metastasis genetic program. Recent integrated studies have synergized clinical bioinformatic analyses with advanced experimental methodology and begun to uncover the identities and dynamics of signaling programs driving breast cancer metastasis. Such functional genomics studies hold great promise for understanding the genetic basis of metastasis and improving therapeutics for advanced diseases.
摘要
基因组分析技术的出现给我们对乳腺癌转移的理解带来了革命性的变化。对原发肿瘤的基因表达分析已被用于高度准确地预测转移倾向。转移的动物模型另外还提供了一个实验性剖析转移遗传程序组成部分的平台。最近的综合研究已经将临床生物信息学分析与先进的实验方法学结合起来，开始揭示驱动乳腺癌转移的信号转导程序的特征和动态。这种功能基因组学研究为理解转移的遗传基础和改进晚期疾病的治疗方法提供了巨大的希望。
相似文献
1
Signaling pathways in breast cancer metastasis - novel insights from functional genomics.乳腺癌转移中的信号通路——功能基因组学的新见解。
Breast Cancer Res. 2011 Mar 14;13(2):206. doi: 10.1186/bcr2831.
2
Increased entropy of signal transduction in the cancer metastasis phenotype.癌症转移表型中信号转导的熵增加。
BMC Syst Biol. 2010 Jul 30;4:104. doi: 10.1186/1752-0509-4-104.
3
Targeting IL13Ralpha2 activates STAT6-TP63 pathway to suppress breast cancer lung metastasis.靶向白细胞介素13受体α2（IL13Rα2）可激活信号转导和转录激活因子6（STAT6）-肿瘤蛋白p63（TP63）通路，从而抑制乳腺癌肺转移。
Breast Cancer Res. 2015 Jul 25;17(1):98. doi: 10.1186/s13058-015-0607-y.
4
New developments in metastatic breast cancer: general discussion.转移性乳腺癌的新进展：综述
Clin Adv Hematol Oncol. 2013;11(10 Suppl 16):16-7.
5
A mouse mammary gland involution mRNA signature identifies biological pathways potentially associated with breast cancer metastasis.一种小鼠乳腺退化mRNA特征可识别出可能与乳腺癌转移相关的生物学途径。
J Mammary Gland Biol Neoplasia. 2009 Jun;14(2):99-116. doi: 10.1007/s10911-009-9120-1. Epub 2009 Apr 30.
6
Genomic pathways modulated by Twist in breast cancer.Twist在乳腺癌中调控的基因组通路。
BMC Cancer. 2017 Jan 13;17(1):52. doi: 10.1186/s12885-016-3033-3.
7
Functional genomic analysis of cancer metastasis: biologic insights and clinical implications.癌症转移的功能基因组分析：生物学见解与临床意义。
Expert Rev Mol Diagn. 2005 May;5(3):385-95. doi: 10.1586/14737159.5.3.385.
8
Comprehensive epigenetic analyses reveal master regulators driving lung metastasis of breast cancer.全面的表观遗传学分析揭示了驱动乳腺癌肺转移的主要调控因子。
J Cell Mol Med. 2019 Aug;23(8):5415-5431. doi: 10.1111/jcmm.14424. Epub 2019 Jun 19.
9
GPNMB cooperates with neuropilin-1 to promote mammary tumor growth and engages integrin α5β1 for efficient breast cancer metastasis.GPNMB 与神经纤毛蛋白-1 合作促进乳腺肿瘤生长，并与整合素 α5β1 结合促进乳腺癌转移。
Oncogene. 2015 Oct;34(43):5494-504. doi: 10.1038/onc.2015.8. Epub 2015 Mar 16.
10
Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics.酮体和乳酸会增加癌细胞的“干性”，从而导致乳腺癌的复发、转移和不良临床结局：通过代谢组学-基因组学实现个体化医疗。
Cell Cycle. 2011 Apr 15;10(8):1271-86. doi: 10.4161/cc.10.8.15330.
引用本文的文献
1
Comprehensive molecular interaction map of TGFβ induced epithelial to mesenchymal transition in breast cancer.TGFβ 诱导乳腺癌上皮间质转化的综合分子相互作用图谱。
NPJ Syst Biol Appl. 2024 May 17;10(1):53. doi: 10.1038/s41540-024-00378-w.
2
Multi-layered knowledge graph neural network reveals pathway-level agreement of three breast cancer multi-gene assays.多层知识图谱神经网络揭示了三种乳腺癌多基因检测在通路水平上的一致性。
Comput Struct Biotechnol J. 2024 Apr 22;23:1715-1724. doi: 10.1016/j.csbj.2024.04.038. eCollection 2024 Dec.
3
The Anti-Cancer Activity of the Naturally Occurring Dipeptide Carnosine: Potential for Breast Cancer.天然二肽肌肽的抗癌活性：乳腺癌的潜在治疗作用。
Cells. 2023 Nov 8;12(22):2592. doi: 10.3390/cells12222592.
4
The Role of Telomerase in Breast Cancer's Response to Therapy.端粒酶在乳腺癌对治疗的反应中的作用。
Int J Mol Sci. 2022 Oct 25;23(21):12844. doi: 10.3390/ijms232112844.
5
Breast cancer metastasis: Is it a matter of OMICS and proper ex-vivo models?乳腺癌转移：这是一个关于组学和合适的体外模型的问题吗？
Comput Struct Biotechnol J. 2022 Jul 28;20:4003-4008. doi: 10.1016/j.csbj.2022.07.044. eCollection 2022.
6
The genomic architecture of metastasis in breast cancer: focus on mechanistic aspects, signalling pathways and therapeutic strategies.乳腺癌转移的基因组结构：聚焦机制、信号通路及治疗策略
Med Oncol. 2021 Jul 16;38(8):95. doi: 10.1007/s12032-021-01547-1.
7
The Metabolic Mechanisms of Breast Cancer Metastasis.乳腺癌转移的代谢机制
Front Oncol. 2021 Jan 7;10:602416. doi: 10.3389/fonc.2020.602416. eCollection 2020.
8
Organotropism: new insights into molecular mechanisms of breast cancer metastasis.器官嗜性：乳腺癌转移分子机制的新见解
NPJ Precis Oncol. 2018 Feb 16;2(1):4. doi: 10.1038/s41698-018-0047-0. eCollection 2018.
9
Inhibition effects of total flavonoids from Sculellaria barbata D. Don on human breast carcinoma bone metastasis via downregulating PTHrP pathway.夏枯草总黄酮通过下调甲状旁腺激素相关肽通路抑制人乳腺癌骨转移。
Int J Mol Med. 2018 Jun;41(6):3137-3146. doi: 10.3892/ijmm.2018.3515. Epub 2018 Feb 27.
10
A Heparin Binding Motif Rich in Arginine and Lysine is the Functional Domain of YKL-40.富含精氨酸和赖氨酸的肝素结合基序是 YKL-40 的功能域。
Neoplasia. 2018 Feb;20(2):182-192. doi: 10.1016/j.neo.2017.11.011. Epub 2017 Dec 20.
本文引用的文献
1
The role of SATB1 in breast cancer pathogenesis.SATB1 在乳腺癌发病机制中的作用。
J Natl Cancer Inst. 2010 Aug 18;102(16):1284-96. doi: 10.1093/jnci/djq243. Epub 2010 Jul 1.
2
In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer.缺氧在乳腺癌原发肿瘤生长和器官特异性转移中的体内动力学及功能差异。
Cancer Res. 2010 May 15;70(10):3905-14. doi: 10.1158/0008-5472.CAN-09-3739. Epub 2010 May 4.
3
Genome remodelling in a basal-like breast cancer metastasis and xenograft.基底样乳腺癌转移和异种移植中的基因组重塑。
Nature. 2010 Apr 15;464(7291):999-1005. doi: 10.1038/nature08989.
4
Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-kappaB-Dependent Manner.癌相关成纤维细胞在早期肿瘤发生时被激活，以 NF-κB 依赖的方式协调促进肿瘤的炎症反应。
Cancer Cell. 2010 Feb 17;17(2):135-47. doi: 10.1016/j.ccr.2009.12.041. Epub 2010 Feb 4.
5
MYC regulation of a "poor-prognosis" metastatic cancer cell state.MYC 调控“预后不良”转移性癌细胞状态。
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3698-703. doi: 10.1073/pnas.0914203107. Epub 2010 Feb 4.
6
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene.大规模多癌症荟萃分析揭示了一种常见的、紧凑的、具有高度预后价值的缺氧综合基因。
Br J Cancer. 2010 Jan 19;102(2):428-35. doi: 10.1038/sj.bjc.6605450.
7
Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis.星形细胞上调基因-1（AEG-1）作为一种癌基因发挥作用，并调节血管生成。
Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21300-5. doi: 10.1073/pnas.0910936106. Epub 2009 Nov 25.
8
Activation of host wound responses in breast cancer microenvironment.激活乳腺癌微环境中的宿主创伤反应。
Clin Cancer Res. 2009 Nov 15;15(22):7020-8. doi: 10.1158/1078-0432.CCR-09-1126. Epub 2009 Nov 3.
9
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution.在单核苷酸分辨率下分析的小叶型乳腺肿瘤中的突变进化。
Nature. 2009 Oct 8;461(7265):809-13. doi: 10.1038/nature08489.
10
Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential.Myc诱导的乳腺肿瘤的遗传异质性反映了包括转移潜能在内的多种表型。
Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16387-92. doi: 10.1073/pnas.0901250106. Epub 2009 Sep 4.
Zotero 插件