基于杀死鼠伤寒沙门氏菌感染的肿瘤细胞的癌症免疫疗法。
Cancer immunotherapy based on the killing of Salmonella typhimurium-infected tumour cells.
作者信息
Saltzman Daniel A
机构信息
University of Minnesota Medical School, 195MMC 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA.
出版信息
Expert Opin Biol Ther. 2005 Apr;5(4):443-9. doi: 10.1517/14712598.5.4.443.
The use of bacteria for anticancer purposes was first attempted over 100 years ago. Recently, several strains of Salmonella have been shown to possess anticancer activity and, interestingly, Salmonella possesses a unique propensity to track to tumour tissue in vivo. This review presents the use of Salmonella for cancer immunotherapy, including the distinguishing characteristics of this organism and preclinical as well as clinical data.
100多年前就有人首次尝试利用细菌来达到抗癌目的。最近，几种沙门氏菌菌株已被证明具有抗癌活性，有趣的是，沙门氏菌在体内具有追踪肿瘤组织的独特倾向。本文综述了沙门氏菌在癌症免疫治疗中的应用，包括该生物体的独特特征以及临床前和临床数据。
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