De Araujo Tami S, Hexsel Camile Luiza, Kirsner Robert S
University of Miami/ Veterans Administration Medical Center, Department of Dermatology, 1201 NW 16th Street,Miami,FL 33125,USA.
Curr Treat Options Cardiovasc Med. 2005 Jun;7(2):131-138. doi: 10.1007/s11936-005-0014-2.
Underlying the pathogenesis of venous ulceration is venous hypertension. Therefore, the use of multilayered compression therapy is the gold standard in the treatment of a venous ulcer. As treatment progresses, an important determinant of response is wound assessment, which should be performed on initial visit and subsequently thereafter. Among the methods to assess improvement are digital photography and planimetry, which are objective methods to measure response to treatment and rate of wound healing. Lack of improvement over a 2- to 4-week period is predictive of eventual lack of response to therapy and suggests the need for adjunctive methods to achieve success, such as oral pentoxifylline, tissue-engineered skin, or skin grafting.
静脉高压是静脉溃疡发病机制的基础。因此，使用多层压迫疗法是治疗静脉溃疡的金标准。随着治疗的进展，反应的一个重要决定因素是伤口评估，应在初次就诊时及随后进行。评估改善情况的方法包括数码摄影和面积测量法，它们是测量治疗反应和伤口愈合率的客观方法。在2至4周内没有改善预示着最终对治疗无反应，并提示需要采用辅助方法来取得成功，如口服己酮可可碱、组织工程皮肤或皮肤移植。
