Smallbone Kieran, Gavaghan David J, Gatenby Robert A, Maini Philip K
Centre for Mathematical Biology, Mathematical Institute, Oxford University, 24-29 St Giles', Oxford, OX1 3LB, UK.
J Theor Biol. 2005 Aug 21;235(4):476-84. doi: 10.1016/j.jtbi.2005.02.001. Epub 2005 Mar 16.
Acidic pH is a common characteristic of human tumours. It has a significant impact on tumour progression and response to therapies. In this paper, we develop a simple model of three-dimensional tumour growth to examine the role of acidosis in the interaction between normal and tumour cell populations. Both vascular and avascular tumour dynamics are investigated, and a number of different behaviours are observed. Whilst an avascular tumour always proceeds to a benign steady state, a vascular tumour may display either benign or invasive dynamics, depending on the value of a critical parameter. Analysis of the model allows us to assess novel therapies directed towards changing the level of acidity within the tumour.
酸性pH值是人类肿瘤的一个常见特征。它对肿瘤进展和治疗反应有重大影响。在本文中，我们建立了一个简单的三维肿瘤生长模型，以研究酸中毒在正常细胞群体与肿瘤细胞群体相互作用中的作用。我们研究了血管生成性肿瘤和无血管生成性肿瘤的动态变化，并观察到了许多不同的行为。虽然无血管生成性肿瘤总是会发展到良性稳定状态，但血管生成性肿瘤可能会表现出良性或侵袭性动态变化，这取决于一个关键参数的值。对该模型的分析使我们能够评估针对改变肿瘤内酸度水平的新型疗法。
