Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Integrated Mathematical Oncology Department, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Trends Cell Biol. 2023 Apr;33(4):300-311. doi: 10.1016/j.tcb.2022.10.006. Epub 2022 Nov 17.
In this opinion, we highlight agent-based modeling as a key tool for exploration of cell-cell and cell-environment interactions that drive cancer progression, therapeutic resistance, and metastasis. These biological phenomena are particularly suited to be captured at the cell-scale resolution possible only within agent-based or individual-based mathematical models. These modeling approaches complement experimental work (in vitro and in vivo systems) through parameterization and data extrapolation but also feed forward to drive new experiments that test model-generated predictions.
在本观点中,我们强调基于代理的建模是探索驱动癌症进展、治疗抵抗和转移的细胞-细胞和细胞-环境相互作用的关键工具。这些生物现象特别适合在基于代理或个体的数学模型中达到的细胞尺度分辨率进行捕捉。这些建模方法通过参数化和数据外推来补充实验工作(体外和体内系统),但也向前反馈以推动新的实验,以测试模型生成的预测。