Bast-Pettersen Rita, Ellingsen Dag G
National Institute of Occupational Health, P.O. Box 8149 Dep., N-0033 Oslo, Norway.
Neurotoxicology. 2005 Jun;26(3):331-42. doi: 10.1016/j.neuro.2005.01.004.
The aim of this study was to compare two tests for tremor/fine motor control as regards their sensitivity in relation to effects on tremor of exposure to manganese and cigarette smoke. One hundred manganese-exposed workers were compared with 100 age-matched referents. The subjects were tested with the Kløve-Matthews static steadiness test (hole tremormeter) and the DPD TREMOR (accelerometer). The manganese-exposed subjects showed increased postural tremor compared to the referents. The tremor had a larger frequency dispersion among the exposed subjects than among the referents as assessed by the TREMOR 7.0 test system, indicating that the tremor had a pattern where the power was burned at a wider spectre of frequencies among the exposed subjects than among the referents. The two tests differed in their ability to demonstrate tremor, depending of the type of exposure (manganese or cigarette smoke). The static steadiness test was better than the TREMOR at discriminating between manganese-exposed subjects and referents while the TREMOR was better at discriminating between smokers and non-smokers than the static steadiness test. The tests also differed in their ability to demonstrate tremor depending on the frequency of tremor. The Tremor Intensity I was higher for subjects with higher tremor frequency, while no such effect was found for the static steadiness test parameters. When studying the effects of exposures where the quality of the tremor is unknown, it is suggested to include at least two tremor tests, one based on acceleration and the other on displacement.
本研究的目的是比较两种震颤/精细运动控制测试在检测锰暴露和吸烟对震颤影响方面的敏感性。将100名锰暴露工人与100名年龄匹配的对照者进行比较。受试者接受了克洛维-马修斯静态稳定性测试(孔震颤计)和DPD震颤测试(加速度计)。与对照者相比,锰暴露受试者的姿势性震颤增加。通过TREMOR 7.0测试系统评估,暴露组受试者的震颤频率离散度大于对照组,这表明暴露组受试者的震颤模式是在更宽的频率范围内消耗能量,而对照组则不然。这两种测试在检测震颤的能力上存在差异,具体取决于暴露类型(锰或香烟烟雾)。在区分锰暴露受试者和对照者方面,静态稳定性测试优于TREMOR测试,而在区分吸烟者和非吸烟者方面,TREMOR测试优于静态稳定性测试。这两种测试在检测不同频率震颤的能力上也存在差异。震颤频率较高的受试者的震颤强度I更高,而静态稳定性测试参数未发现这种影响。在研究震颤性质未知的暴露影响时,建议至少包括两种震颤测试,一种基于加速度,另一种基于位移。