National Institute of Occupational Health, P.O. Box 8149 Dep, 0033, Oslo, Norway.
Northwest State Medical University named after I.I. Mechnikov, 191015, St. Petersburg, Russia.
Int Arch Occup Environ Health. 2019 Apr;92(3):383-394. doi: 10.1007/s00420-019-01415-6. Epub 2019 Feb 21.
There is a lack of knowledge about neurobehavioral performance among patients with manganism and how their performance differs from that of idiopathic Parkinson disease patients (PD). This study was initiated with the aim to describe and compare neurobehavioral performance among patients diagnosed with manganism, PD and a group of referents.
Neurobehavioral performance was assessed in 34 patients diagnosed with manganism, 13 with PD, and 43 healthy workers (turners/fitters) who served as the reference group. Seventeen of the manganism patients had also been tested approximately 65 months previously.
Manganism patients scored substantially more poorly than referents on tests for motor speed, manual dexterity and balance. They also performed more poorly than the PD patients on the postural sway test. In contrast, the PD patients had higher postural tremor intensity with narrower frequency dispersion than manganism patients. The pattern of neurobehavioral performance was more asymmetrical in PD compared to manganism patients, in particular when testing for tremor intestity, grooved pegboard and static steadiness, indicating lateralized impairment in the PD patients. The amount of bradykinesia was comparable between the patient groups. Neurobehavioral performance deteriorated slightly among 17 manganism patients followed for 65 months compared with the age-related decline among referents.
Patients with manganism had severe bradykinesia and balance disturbances, but only slight postural tremor. In contrast, PD patients had significant postural tremor and bradykinesia, but only slight balance disturbances. Their neurobehavioral performance indicated lateralized impairment, more unilateral. Neurobehavioral performance deteriorated slightly in manganism patients during a 65-month follow-up.
对于锰中毒患者的神经行为表现及其与特发性帕金森病（PD）患者的差异，人们知之甚少。本研究旨在描述和比较诊断为锰中毒、PD 和一组参照者的患者的神经行为表现。
对 34 名被诊断为锰中毒的患者、13 名 PD 患者和 43 名健康工人（车工/钳工）进行了神经行为表现评估，后者作为参照组。17 名锰中毒患者还在大约 65 个月前接受了测试。
与参照者相比，锰中毒患者在运动速度、手灵活性和平衡方面的得分明显较低。与 PD 患者相比，他们在姿势摆动测试中的表现也较差。相比之下，PD 患者的姿势震颤强度较高，频散较窄。与锰中毒患者相比，PD 患者的神经行为表现模式更为不对称，特别是在测试震颤强度、槽形钉板和静态稳定性时，表明 PD 患者存在侧化损伤。两组患者的运动迟缓程度相当。17 名被随访 65 个月的锰中毒患者的神经行为表现略有恶化，与参照者的年龄相关下降相比。
锰中毒患者有严重的运动迟缓伴平衡障碍，但只有轻微的姿势震颤。相比之下，PD 患者有显著的姿势震颤和运动迟缓，但只有轻微的平衡障碍。他们的神经行为表现表明存在侧化损伤，更单侧化。在 65 个月的随访中，锰中毒患者的神经行为表现略有恶化。
