Kohl Claudia, Walch Thomas, Huber Regina, Kemmler Georg, Neurauter Gabriele, Fuchs Dietmar, Sölder Elisabeth, Schröcksnadel Hans, Sperner-Unterweger Barbara
Department of Psychiatry, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria.
J Affect Disord. 2005 Jun;86(2-3):135-42. doi: 10.1016/j.jad.2004.12.013.
Activation of the tryptophan-degrading enzyme indoleamine (2,3)-dioxygenase was demonstrated to be critically involved in tolerance induction to prevent fetal rejection. Our study was designed to examine alterations of tryptophan and its catabolic product kynurenine in the postpartum period and to compare them to neopterin as an immunological marker.
95 healthy women delivering without complications provided blood during labour, and 2 and 4 days after birth. The blood samples were analysed for concentrations of tryptophan, kynurenine and neopterin. Women were asked to perform the Edinburgh Postnatal Depression Scale (EPDS) on days 2 and 4.
In women without blues symptoms (n=86) tryptophan concentrations increased within 2 days after birth, whereas they did not change in women with postpartum blues (n=9; 9.5%). The group difference reached statistical significance (p<0.05). The change of the kynurenine to tryptophan ratio (kyn/trp), which estimates the degree of tryptophan degradation, was also different between the two groups at days 0 and 2 (p<0.05). Neopterin concentrations decreased between days 2 and 4 (p<0.05), but there were no differences between the two groups.
Our study population had a low prevalence of postpartum blues symptoms.
Low postpartal mood is associated with continuously low serum tryptophan after delivery due to an increased degradation to kynurenine, but is independent of the postpartal course of neopterin.
已证明色氨酸降解酶吲哚胺2,3-双加氧酶的激活在诱导耐受性以防止胎儿排斥反应中起关键作用。我们的研究旨在检查产后时期色氨酸及其分解代谢产物犬尿氨酸的变化，并将它们与作为免疫标志物的新蝶呤进行比较。
95名无并发症分娩的健康女性在分娩期间、产后2天和4天提供血液样本。分析血样中色氨酸、犬尿氨酸和新蝶呤的浓度。要求女性在第2天和第4天进行爱丁堡产后抑郁量表（EPDS）测试。
在没有产后情绪低落症状的女性（n = 86）中，色氨酸浓度在产后2天内升高，而在有产后情绪低落的女性（n = 9；9.5%）中则没有变化。两组差异具有统计学意义（p < 0.05）。估计色氨酸降解程度的犬尿氨酸与色氨酸比值（kyn/trp）在第0天和第2天两组之间也存在差异（p < 0.05）。新蝶呤浓度在第2天和第4天之间下降（p < 0.05），但两组之间没有差异。
我们的研究人群中产后情绪低落症状的患病率较低。
产后情绪低落与分娩后血清色氨酸持续处于低水平有关，这是由于其向犬尿氨酸的降解增加，但与新蝶呤的产后变化过程无关。
