中风后痴呆与α1-抗糜蛋白酶多态性有关。
Post-stroke dementia is associated with alpha(1)-antichymotrypsin polymorphism.
作者信息
Klimkowicz Aleksandra, Słowik Agnieszka, Dziedzic Tomasz, Polczyk Romuald, Szczudlik Andrzej
机构信息
Department of Neurology, Collegium Medicum, Jagiellonian University, 31-503 Cracow, Botaniczna 3, Poland.
出版信息
J Neurol Sci. 2005 Jul 15;234(1-2):31-6. doi: 10.1016/j.jns.2005.02.012.
BACKGROUND AND PURPOSE
Alpha-1-antichymotrypsin (ACT) is an acute phase protein involved in inflammatory reaction, promoting the assembly of beta amyloid protein into filaments and contributing to its resistance to proteolytic digestion. The aim of our study was to determine ACT signal peptide polymorphism (A/T) as a possible risk factor for post-stroke dementia (PSD).
METHODS
142 consecutive ischemic stroke patients and 188 controls were included in this study. Pre-stroke dementia (PRESD) was evaluated using the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). The diagnosis of the post-stroke dementia (PSD) was established according to DSM-IV criteria. The ACT gene (A/T) polymorphism was determined by PCR-RFLR.
RESULTS
Both ACT-TT genotype and T-allele were significantly more prevalent in patients with PSD than in non-demented stroke patients, controls or patients with PRESD. After adjustment for age, gender, and vascular risk factors, both the ACT-TT genotype and T-allele remained independently associated with PSD.
CONCLUSION
Our findings suggest that ACT polymorphism (A/T) is a risk factor for PSD.
背景与目的
α1抗糜蛋白酶（ACT）是一种参与炎症反应的急性期蛋白，可促进β淀粉样蛋白组装成细丝，并增强其对蛋白水解消化的抵抗力。我们研究的目的是确定ACT信号肽多态性（A/T）作为卒中后痴呆（PSD）的一个可能危险因素。
方法
本研究纳入了142例连续性缺血性卒中患者和188例对照。使用老年人认知功能减退知情者问卷（IQCODE）评估卒中前痴呆（PRESD）。根据DSM-IV标准诊断卒中后痴呆（PSD）。通过聚合酶链反应-限制性片段长度多态性（PCR-RFLR）确定ACT基因（A/T）多态性。
结果
与非痴呆性卒中患者、对照或PRESD患者相比，PSD患者中ACT-TT基因型和T等位基因的发生率均显著更高。在对年龄、性别和血管危险因素进行校正后，ACT-TT基因型和T等位基因仍与PSD独立相关。
结论
我们的研究结果表明，ACT多态性（A/T）是PSD的一个危险因素。
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